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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
1992-11-18
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pubmed:databankReference |
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pubmed:abstractText |
T lymphocytes exhibit three distinct types of voltage-gated K+ channels, n, n', and l, that are distributed in the T cell lineage according to subset, as well as the cells' activation and developmental status. Type l K+ channels are found sparingly in cytotoxic T cells from normal mice and abundantly in a specific T cell subset (CD4- CD8- Thy1+) from mice with autoimmune disease. Here, we show that the mouse Kv3.1 gene, when expressed in Xenopus oocytes, encodes a channel with properties remarkably similar to those of the l-type channel. Kv3.1 transcripts were found in T cells isolated from the lymph nodes of MRL-lpr mice with systemic lupus erythematosus and in a human lymphoma cell line that also expresses the l channel phenotype. By these criteria, we conclude that Kv3.1 encodes the voltage-gated type l K+ channel in lymphocytes. The Kv3.1 gene maps to human chromosome 11; the related Kv1.1 and Kv3.2 genes are localized on human chromosome 12, while the IsK gene maps to human chromosome 21.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
267
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pubmed:geneSymbol |
IsK,
Kv3.1,
hkv3.1,
mKv3.1,
rKv3.1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20971-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1400413-Amino Acid Sequence,
pubmed-meshheading:1400413-Animals,
pubmed-meshheading:1400413-Base Sequence,
pubmed-meshheading:1400413-Cell Line,
pubmed-meshheading:1400413-Chromosome Mapping,
pubmed-meshheading:1400413-Chromosomes, Human, Pair 11,
pubmed-meshheading:1400413-Cloning, Molecular,
pubmed-meshheading:1400413-DNA,
pubmed-meshheading:1400413-Humans,
pubmed-meshheading:1400413-Membrane Potentials,
pubmed-meshheading:1400413-Mice,
pubmed-meshheading:1400413-Molecular Sequence Data,
pubmed-meshheading:1400413-Neuropeptides,
pubmed-meshheading:1400413-Oligodeoxyribonucleotides,
pubmed-meshheading:1400413-Oocytes,
pubmed-meshheading:1400413-Polymerase Chain Reaction,
pubmed-meshheading:1400413-Potassium Channels,
pubmed-meshheading:1400413-Potassium Channels, Voltage-Gated,
pubmed-meshheading:1400413-RNA, Messenger,
pubmed-meshheading:1400413-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1400413-Shaw Potassium Channels,
pubmed-meshheading:1400413-T-Lymphocytes,
pubmed-meshheading:1400413-Xenopus
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pubmed:year |
1992
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pubmed:articleTitle |
The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells.
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pubmed:affiliation |
Department of Physiology and Biophysics, University of California, Irvine 92715.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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