1400225

Source:http://linkedlifedata.com/resource/pubmed/id/1400225

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004595, umls-concept:C0008633, umls-concept:C0014834, umls-concept:C0162657, umls-concept:C0205147, umls-concept:C1327729, umls-concept:C1334043, umls-concept:C1521761, umls-concept:C1524072, umls-concept:C2362924, umls-concept:C2700640
pubmed:issue	21
pubmed:dateCreated	1992-11-25
pubmed:databankReference	http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L13279, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/L13280, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M85240, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M85241, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94367, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M95582, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X64378, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X64379, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X64380, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X64381
pubmed:abstractText	Mutation of the divIVB locus in Bacillus subtilis causes frequent misplacement of the division septum, resulting in circular minicells, short rods, and filaments of various sizes. The divIVB1 mutant allele maps to a region of the chromosome also known to encode sporulation (spo0B, spoIVF, spoIIB) and cell shape (rodB) determinants. This study reports the cloning and sequence analysis of 4.4 kb of the B. subtilis chromosome encompassing the divIVB locus. This region contains five open reading frames (ORFs) arranged in two functionally distinct gene clusters (mre and min) and transcribed colinearly with the direction of replication. Although sequence analysis reveals potential promoters preceding each gene cluster, studies with integrational plasmids suggest that all five ORFs are part of a single transcription unit. The first gene cluster contains three ORFs (mreBCD) homologous to the mre genes of Escherichia coli. We show that rodB1 is allelic to mreD and identify the rodB1 mutation. The second gene cluster contains two ORFs (minCD) homologous to minC and minD of E. coli but lacks a minE homolog. We show that divIVB1 is allelic to minD and identify two mutations in the divIVB1 allele. Insertional inactivation of either minC or minD or the presence of the divIVB region on plasmids produces a severe minicell phenotype in wild-type cells. Moreover, E. coli cells carrying the divIVB region on a low-copy-number plasmid produce minicells, suggesting that a product of this locus may retain some function across species boundaries.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM37990
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1400224, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1655695, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-16591472, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1712357, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1729222, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1836760, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1848202, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1942049, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-19424, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-1944597, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2088169, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2137246, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2183414, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2201955, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2211516, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2432055, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2507871, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2645057, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2656641, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2687239, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2822655, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2823077, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-2834323, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-3025556, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-3049542, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-3139638, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-3162770, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-322279, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-4110922, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-4196259, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-4204911, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-6092222, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-6181373, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-6290454, http://linkedlifedata.com/resource/pubmed/commentcorrection/1400225-7108955
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2985120R
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Nov
pubmed:issn	0021-9193
pubmed:author	pubmed-author:StewartG CGC, pubmed-author:VarleyA WAW
pubmed:issnType	Print
pubmed:volume	174
pubmed:geneSymbol	MinCD
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	6729-42
pubmed:dateRevised	2010-9-7
pubmed:meshHeading	pubmed-meshheading:1400225-Alleles, pubmed-meshheading:1400225-Amino Acid Sequence, pubmed-meshheading:1400225-Bacillus subtilis, pubmed-meshheading:1400225-Base Sequence, pubmed-meshheading:1400225-Cell Division, pubmed-meshheading:1400225-Chromosome Mapping, pubmed-meshheading:1400225-Chromosomes, Bacterial, pubmed-meshheading:1400225-Cloning, Molecular, pubmed-meshheading:1400225-Genes, Bacterial, pubmed-meshheading:1400225-Molecular Sequence Data, pubmed-meshheading:1400225-Morphogenesis, pubmed-meshheading:1400225-Multigene Family, pubmed-meshheading:1400225-Mutagenesis, Insertional, pubmed-meshheading:1400225-Open Reading Frames, pubmed-meshheading:1400225-Protein Structure, Secondary, pubmed-meshheading:1400225-Sequence Homology, Amino Acid
pubmed:year	1992
pubmed:articleTitle	The divIVB region of the Bacillus subtilis chromosome encodes homologs of Escherichia coli septum placement (minCD) and cell shape (mreBCD) determinants.
pubmed:affiliation	Department of Microbiology, University of Kansas, Lawrence 66045.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.