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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1992-11-6
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pubmed:abstractText |
Preclinical studies performed in our laboratory showed that mouse leukemias become highly immunogenic following in vivo treatment with Decarbazine. This observation led to a successful immunochemotherapy protocol in mice using Dacarbazine plus cytoreductive chemotherapy. Therefore an in vivo and in vitro pilot study was conducted in patients (pts) with resistant or relapsed acute myelogenous leukemia (AML). The DNA-repair enzyme O6-alkylguanine-DNA-alkyl-transferase (OGAT) and the in vitro chemosensitivity to Temozolomide, a Dacarbazine derivative, were evaluated in leukemic blasts.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0390-6078
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-50
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1398299-Antiemetics,
pubmed-meshheading:1398299-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1398299-Blast Crisis,
pubmed-meshheading:1398299-Bone Marrow,
pubmed-meshheading:1398299-Dacarbazine,
pubmed-meshheading:1398299-Drug Resistance,
pubmed-meshheading:1398299-Humans,
pubmed-meshheading:1398299-Leukemia, Myeloid, Acute,
pubmed-meshheading:1398299-Leukemia, Myelomonocytic, Acute,
pubmed-meshheading:1398299-Methyltransferases,
pubmed-meshheading:1398299-Nausea,
pubmed-meshheading:1398299-Neoplastic Stem Cells,
pubmed-meshheading:1398299-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:1398299-Pilot Projects,
pubmed-meshheading:1398299-Remission Induction
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pubmed:articleTitle |
Cytotoxic effects of dacarbazine in patients with acute myelogenous leukemia: a pilot study.
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pubmed:affiliation |
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, II Università, Roma, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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