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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-11-19
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pubmed:abstractText |
1. The novel choline analogs selenonium choline (SeCh) and acetylselenonium choline (ASeCh) have been examined for selected biological activities. 2. ASeCh was found to be an alternative substrate for acetylcholine esterase with Km and Vmax values similar to acetylcholine. 3. ASeCh and SeCh inhibited acetylthiocholine hydrolysis by acetylcholinesterase with IC50 values similar to acetylcholine and choline. 4. SeCh exerted a protective action against physostigmine and DFP induced toxicity. 5. SeCh (85 mg/kg) was found to be 3 times more toxic in mice than choline.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
689-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1397975-Acetylcholine,
pubmed-meshheading:1397975-Acetylcholinesterase,
pubmed-meshheading:1397975-Animals,
pubmed-meshheading:1397975-Choline,
pubmed-meshheading:1397975-Cholinesterase Inhibitors,
pubmed-meshheading:1397975-Hydrolysis,
pubmed-meshheading:1397975-Isoflurophate,
pubmed-meshheading:1397975-Kinetics,
pubmed-meshheading:1397975-Male,
pubmed-meshheading:1397975-Mice,
pubmed-meshheading:1397975-Mice, Inbred ICR,
pubmed-meshheading:1397975-Organoselenium Compounds,
pubmed-meshheading:1397975-Physostigmine
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pubmed:year |
1992
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pubmed:articleTitle |
Selected biological activities of novel selenonium choline analogs.
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pubmed:affiliation |
College of Pharmacy, University of South Carolina, Columbia 29208.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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