Linked Life Data

13974244

Source:http://linkedlifedata.com/resource/pubmed/id/13974244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1963-12-1
pubmed:abstractText
Roberson, Bob S. (University of North Carolina, Chapel Hill) and William J. Cromartie. Influence of the physical state of endotoxic preparations on their dermal toxicity. J. Bacteriol. 84:882-887. 1962.-Studies were performed with various preparations of endotoxin from Escherichia coli to test for a possible relation between the physical state or degree of aggregation of the toxin and dermal toxicity. Endotoxic fractions were prepared by enzymatic and physical dissolution of cell walls, phenol extraction, and ether extraction. A comparison of the toxic effects of the different preparations after a single intradermal injection into rabbits demonstrated that the degree and duration of the inflammatory response was influenced significantly by the physical state of the preparation. In addition, the least active material, the aqueous ether extract, was treated so as to yield three preparations differing only in the degree of aggregation. Dermal titration of these preparations suggests that a departure from an optimal range of particle size results in a diminished capacity of endotoxin to induce the acute and protracted manifestations of dermal response.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
882-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1962
pubmed:articleTitle
Influence of the physical state of endotoxic preparations on dermal toxicity.
pubmed:publicationType
Journal Article