rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1992-11-25
|
pubmed:databankReference |
|
pubmed:abstractText |
We have determined the full-length cDNA sequence of the human alpha 1(X) collagen gene by sequence analysis of a genomic clone ERG [(1991) Dev. Biol. 148, 562-572], and of cDNA fragments generated from a reverse transcribed as alpha 1(X) mRNA by PCR. We defined the promoter region, the transcription initiation site and the full-length 5'-untranslated region. We also report the exon/intron boundaries of the transcript and the complete 3'-untranslated region as well as a 3'-flanking sequence containing two additional polyadenylation signals. The promoter region is homologous to chicken and mouse type X promoters within several highly conserved regions. The genomic organization shows high homologies to chicken and mouse.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
26
|
pubmed:volume |
311
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
305-10
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:1397333-Amino Acid Sequence,
pubmed-meshheading:1397333-Animals,
pubmed-meshheading:1397333-Base Sequence,
pubmed-meshheading:1397333-Chickens,
pubmed-meshheading:1397333-Collagen,
pubmed-meshheading:1397333-DNA,
pubmed-meshheading:1397333-Genomic Library,
pubmed-meshheading:1397333-Molecular Sequence Data,
pubmed-meshheading:1397333-Oligodeoxyribonucleotides,
pubmed-meshheading:1397333-Polymerase Chain Reaction,
pubmed-meshheading:1397333-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1397333-Restriction Mapping,
pubmed-meshheading:1397333-Sequence Homology, Nucleic Acid
|
pubmed:year |
1992
|
pubmed:articleTitle |
Genomic organization and full-length cDNA sequence of human collagen X.
|
pubmed:affiliation |
Max-Planck Society, University of Erlangen-Nürnberg, Germany.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|