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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-11-25
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pubmed:databankReference |
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pubmed:abstractText |
A mouse somatostatin (SS) receptor cDNA was cloned from neuroblastoma x glioma (NG108-15) cells. The sequence is almost identical to that of the mouse SSTR2 receptor [(1992) Proc. Natl. Acad. Sci. USA 89, 251)] but lacks about 300 nucleotides between transmembrane domain VII and the C-terminus. This spliced variant of SSTR2 (designated SSTR2B) encodes a protein which is 23 residues shorter than that predicted from the SSTR2 sequence, and differs in 15 amino acids at the C-terminus. mRNA corresponding to SSTR2B occurs in mouse tissues in higher abundance than that of SSTR2. SSTR2B binds SS peptides with high affinity when expressed in mammalian cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
311
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1397330-Amino Acid Sequence,
pubmed-meshheading:1397330-Animals,
pubmed-meshheading:1397330-Base Sequence,
pubmed-meshheading:1397330-Blotting, Northern,
pubmed-meshheading:1397330-Cloning, Molecular,
pubmed-meshheading:1397330-DNA,
pubmed-meshheading:1397330-Gene Expression,
pubmed-meshheading:1397330-Glioma,
pubmed-meshheading:1397330-Humans,
pubmed-meshheading:1397330-Hybrid Cells,
pubmed-meshheading:1397330-Kinetics,
pubmed-meshheading:1397330-Mice,
pubmed-meshheading:1397330-Molecular Sequence Data,
pubmed-meshheading:1397330-Neuroblastoma,
pubmed-meshheading:1397330-Polymerase Chain Reaction,
pubmed-meshheading:1397330-RNA, Messenger,
pubmed-meshheading:1397330-Receptors, Somatostatin,
pubmed-meshheading:1397330-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1397330-Transcription, Genetic,
pubmed-meshheading:1397330-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Cloning and expression of a novel mouse somatostatin receptor (SSTR2B).
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pubmed:affiliation |
Department of Physiology, University of Munich, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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