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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1963-12-1
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pubmed:abstractText |
Guinea pig 7Sgamma(2) antibodies were demonstrated to fix complement in the presence of antigen and to sensitize antigen-coated, tanned erythrocytes for lysis in the presence of complement; guinea pig 7Sgamma(1) antibodies did not participate in these reactions. Gamma-2 antibodies were more efficient in provoking hemorrhagic necrosis in reverse passive Arthus reactions than equal amounts of non-complement-fixing gamma-1 antibodies. Unlike anaphylaxis in the guinea pig, both guinea pig 7Sgamma(1) and 7Sgamma(2) antibodies provoked passive cutaneous anaphylactic reactions in the rat. Efficient hemolytic activity attributable to 7S guinea pig anti-sheep erythrocyte antibodies migrated faster than the peak of complement-fixing activity, but slower than the peak of PCA activity in starch block electrophoresis. It is uncertain whether this activity is a function of a third type of antibody produced in response to the particulate property of the antigen or whether it is due to the antigenic heterogeneity of the erythrocyte cell membrane.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13163409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13481246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13549644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13579002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13611297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13673141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13731744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13810816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13872176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13919639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13939962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13940786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-13967257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-14888816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/13971679-15400496
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pubmed:keyword |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
OM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
965-81
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
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pubmed:year |
1963
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pubmed:articleTitle |
Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis.
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pubmed:publicationType |
Journal Article
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