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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1992-11-13
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pubmed:abstractText |
In the present study, we describe the effects of Ca2+ channel antagonist (verapamil) on [3H]acetylcholine (ACh) release in the central nervous system of spontaneously hypertensive rats (SHR). The electrically stimulated release of [3H]ACh from striatal slices was not different between SHR and normotensive Wistar Kyoto (WKY) rats. Verapamil inhibited electrically stimulated [3H]ACh release in a dose-related fashion. The inhibitory effect of verapamil was significantly greater in SHR than in WKY rats. These results suggest that the Ca2+ sensitivity of central cholinergic neurons might be enhanced in SHR, which could attribute, at least partially, to the pathogenesis of hypertension.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
5
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pubmed:volume |
216
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
319-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1397017-Acetylcholine,
pubmed-meshheading:1397017-Animals,
pubmed-meshheading:1397017-Corpus Striatum,
pubmed-meshheading:1397017-Male,
pubmed-meshheading:1397017-Rats,
pubmed-meshheading:1397017-Rats, Inbred SHR,
pubmed-meshheading:1397017-Rats, Inbred WKY,
pubmed-meshheading:1397017-Verapamil
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pubmed:year |
1992
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pubmed:articleTitle |
Effects of verapamil on [3H]acetylcholine release in the striatum of spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Medicine, Wakayama Medical College, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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