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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1992-11-18
|
| pubmed:abstractText |
The relationship among neuropeptide Y (NPY), catecholamines and haemodynamics was assessed both at baseline and during inotropic intervention in patients with congestive heart failure. Eighteen patients with idiopathic dilated cardiomyopathy (left ventricular ejection fraction (LVEF) = 26 +/- 10%) underwent both right and left catheterization. Haemodynamic parameters were recorded at baseline and during dobutamine infusion. To measure norepinephrine (NE), epinephrine (E) (nmol.l-1: radioenzymatic assay) and NPY (pmol.l-1: immunoradiometric assay) plasma concentrations, blood samples were drawn from the femoral artery and from the coronary sinus, both at baseline and during dobutamine infusion. At baseline, NPY concentration were 2.15 +/- 0.97 pmol.l-1 in the femoral artery and 1.97 +/- 0.63 pmol.l-1 in the coronary sinus. Peripheral concentrations of NPY were, however, no different from those of patients without congestive heart failure: 2.4 +/- 2.7 pmol.l-1. Peripheral NE concentration was correlated to haemodynamic parameters: LVEF (r = -0.65; P less than 0.01), cardiac index (r = -0.54; P less than 0.05), LV end-diastolic pressure (r = +0.59; P less than 0.05), while peripheral NPY and E concentrations were not. Dobutamine improved haemodynamics, since cardiac index increased by 30% and LV end-diastolic pressure decreased by 40% (P less than 0.01). Peripheral NE concentration decreased from 6.48 +/- 4.5 to 4.82 +/- 2.69 nmol.l-1 (P less than 0.05) but there was no change in E (0.99 +/- 0.61 vs 1.04 +/- 0.74 nmol.l-1) or NPY concentrations (2.41 +/- 0.99 pmol.l-1). In the coronary sinus, neither NE nor NPY concentrations changed during dobutamine infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0195-668X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1233-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:1396834-Adult,
pubmed-meshheading:1396834-Cardiac Output,
pubmed-meshheading:1396834-Cardiomyopathy, Dilated,
pubmed-meshheading:1396834-Chronic Disease,
pubmed-meshheading:1396834-Coronary Vessels,
pubmed-meshheading:1396834-Dobutamine,
pubmed-meshheading:1396834-Dose-Response Relationship, Drug,
pubmed-meshheading:1396834-Epinephrine,
pubmed-meshheading:1396834-Female,
pubmed-meshheading:1396834-Heart Failure,
pubmed-meshheading:1396834-Hemodynamics,
pubmed-meshheading:1396834-Humans,
pubmed-meshheading:1396834-Infusions, Intra-Arterial,
pubmed-meshheading:1396834-Male,
pubmed-meshheading:1396834-Middle Aged,
pubmed-meshheading:1396834-Neuropeptide Y,
pubmed-meshheading:1396834-Norepinephrine,
pubmed-meshheading:1396834-Sympathetic Nervous System
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Relationship among neuropeptide Y, catecholamines and haemodynamics in congestive heart failure.
|
| pubmed:affiliation |
Service de Cardiologie, Hopital Universitaire Henri Mondor, Créteil, France.
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| pubmed:publicationType |
Journal Article
|