Linked Life Data

13965240

Source:http://linkedlifedata.com/resource/pubmed/id/13965240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1963-12-1
pubmed:abstractText
A rise of body temperature into a range lethal to mice preceded death in groups of mice injected with amphetamine sulphate. At dose levels from 8.8 to 66.7 mg/kg, mortality was associated with the extent of rise in body temperature of the mice, irrespective of the actual dose administered. Isolated mice given comparable doses of amphetamine also showed a marked increase in body temperature. However, except in a very few cases, it did not rise into the range found to be lethal. Amphetamine was more toxic to isolated mice subjected to foot-shock than to isolated mice housed under normal conditions. This has also been shown to be related to the extent of rise in body temperature of the mice. The effect of a number of substances on grouped amphetamine toxicity was investigated. Chlorpromazine and phenoxybenzamine partially antagonized the sharp rise in temperature following the administration of amphetamine, and also significantly reduced mortality. Calcium acetylsalicylate was without effect on the rise of body temperature or on mortality. Both the hypothermic compound 4-methyl-5-(beta-chlorethyl)-thiazole (S.C.T.Z.) and L-thyroxine sodium potentiated the rise in temperature and caused a significant increase in mortality.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0366-0826
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-57
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1962
pubmed:articleTitle
Hyperpyrexia as a contributory factor in the toxicity of amphetamine to aggregated mice.
pubmed:publicationType
Journal Article