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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-3
|
| pubmed:dateCreated |
1992-11-2
|
| pubmed:abstractText |
We have followed up 63 pregnancies in women with autoimmune thrombocytopenic purpura (ATP). Of these, 15 were previously splenectomized. The characteristics of the sample can be summed up as follows: average age 27 years (17-41); platelets at the beginning of pregnancy, mean 129.5 x 10(9)/l (range 16-488); platelets at delivery, mean 133 x 10(9)/l (range 8-477); PA-IgG at delivery, mean 320 ng IgG/10(7) platelets (range 10-1000); SPB-IgG at delivery, mean 262 ng IgG/10(7) platelets (range 10-1000). There were 30 spontaneous deliveries and 33 cesarean sections. Forty-two newborns had a platelet count within the normal range while nine had a platelet count less than or equal to 150 x 10(9)/l, while six had less than or equal to 100 x 10(9)/l and a further six less than or equal to 50 x 10(9)/l. The aim of this study is the evaluation of maternal risk and of possible feto-neonatal thrombocytopenia at birth. In this regard, the following parameters were considered: previous maternal splenectomy; the platelet count at the beginning of pregnancy; the platelet count and the titres of PA-IgG and SPB-IgG at delivery. Preliminary statistical evaluation of these parameters enabled us to identify a risk score. From this it was possible to obtain an optimum management of the final stage of pregnancy regarding the therapeutic approach and the timing of delivery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0378-3782
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
143-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1396227-Cesarean Section,
pubmed-meshheading:1396227-Female,
pubmed-meshheading:1396227-Fetal Diseases,
pubmed-meshheading:1396227-Hemorrhage,
pubmed-meshheading:1396227-Humans,
pubmed-meshheading:1396227-Infant, Newborn,
pubmed-meshheading:1396227-Platelet Count,
pubmed-meshheading:1396227-Pregnancy,
pubmed-meshheading:1396227-Pregnancy Complications, Hematologic,
pubmed-meshheading:1396227-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:1396227-Risk Factors,
pubmed-meshheading:1396227-Spleen,
pubmed-meshheading:1396227-Splenectomy
|
| pubmed:articleTitle |
Autoimmune thrombocytopenic purpura: maternal and fetal disease.
|
| pubmed:affiliation |
Institute of Puericulture, University of Rome, La Sapienza, Italy.
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| pubmed:publicationType |
Journal Article
|