Linked Life Data

1396050

Source:http://linkedlifedata.com/resource/pubmed/id/1396050

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-11-23
pubmed:abstractText
Nephrotoxicity was studied in 47 patients who received combined chemotherapy with cisplatin (DDP, 50-100 mg/m2) as the chief agent. The treatment was given every 3-4 weeks with vigorous hydration and forced diuresis. The renal tubular toxicity was evaluated by urinary beta 2 microglobulin (beta 2-MG). It was found that the nephrotoxicity secondary to DDP was dose-dependent. Hypertonic saline was able to decrease the renal damage without any significant difference among the first, second and third course. The nephrotoxicity of DDP administered in one day was more severe than that given in two days. beta 2-MG was a good parameter of DDP nephrotoxicity. By multivariate statistical analysis, metoclopramid and chlorpromazine were found to alleviate DDP nephrotoxicity. Classification, examination and management of DDP nephrotoxicity is proposed.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0253-3766
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Clinical multivariate statistical analysis of nephrotoxicity induced by cisplatin].
pubmed:affiliation
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
pubmed:publicationType
Journal Article, English Abstract