Linked Life Data

13956570

Source:http://linkedlifedata.com/resource/pubmed/id/13956570

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1963-12-1
pubmed:abstractText
Contractions of isolated strips of cat spleen due to 5-hydroxytryptamine, adrenaline, histamine and acetylcholine were antagonized by phenoxybenzamine. Responses to both 5-hydroxytryptamine and adrenaline were not blocked in strips which were protected by a high concentration of either 5-hydroxytryptamine or adrenaline throughout exposure to phenoxybenzamine. The contraction due to a large dose of 5-hydroxytryptamine lasted less than 1 hr even when the drug was still present. Strips thus desensitized to 5-hydroxytryptamine responded normally to acetylcholine and histamine but did not respond to adrenaline. The actions of 5-hydroxytryptamine and adrenaline were blocked by 2-bromolysergic acid diethylamide or by dihydroergotamine. These results indicated that 5-hydroxytryptamine and adrenaline act on the same receptors. Cocaine potentiated the action of adrenaline but inhibited the action of 5-hydroxytryptamine. The sensitivity to 5-hydroxytryptamine of spleen strips from cats treated 24 hr earlier with reserpine was only one-fiftieth of that of normal strips. Cocaine potentiated the action of 5-hydroxytryptamine on strips from reserpine-treated cats. A high concentration of 5-hydroxytryptamine in spleen strips from reserpine-treated cats and in cocaine-treated strips prevented phenoxybenzamine from blocking the actions of adrenaline. The effects of tyramine on spleen strips almost exactly paralleled the effects of 5-hydroxytryptamine. Strips showing tachyphylaxis to tyramine did not respond to 5-hydroxytryptamine. It is concluded that 5-hydroxytryptamine has a dual action, viz., a major action due to release of stored noradrenaline and a minor direct action of adrenaline receptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13035757, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13066124, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13155764, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13172437, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13175108, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13412188, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13460238, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13611696, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13727081, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13844323, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-13906918, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-14371990, http://linkedlifedata.com/resource/pubmed/commentcorrection/13956570-14417792
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0366-0826
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1962
pubmed:articleTitle
An action of 5-hydroxytryptamine on adrenaline receptors.
pubmed:publicationType
Journal Article