Linked Life Data

1394967

Source:http://linkedlifedata.com/resource/pubmed/id/1394967

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-11-16
pubmed:abstractText
The monoclonal antibody designated as F84.1 was used for an immunohistochemical study of the developing rat nervous system. The most prominent neural components recognized by F84.1 are motor and sensory components of the spinal cord and cranial nerves. F84.1 is first detected in the dorsal root ganglia of embryonic day 11 spinal cord. The expression in the dorsal roots persists in the adult. In contrast, a more transient expression of F84.1 is found in the spinal motor system. F84.1 labels primary neurons of cranial nerves V, VIII, IX and X. F84.1 is also expressed by the non-neuronal cells of the notochord and the floor plate. Immunoprecipitation experiments from several types of cells in culture show that the F84.1 antigen is a cell-surface glycoprotein with a molecular weight of 90-105 kDa. An analysis of the amino terminal sequence demonstrates that the F84.1 antigen is similar to the chick cell adhesion molecule SC1/DM-GRASP, a member of the immunoglobulin superfamily. The pattern of expression of F84.1 in the rat differs in several aspects from that of the chick molecules, leaving a possibility that F84.1 may be a variant of SC1/DM-GRASP.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-201
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Expression of the F84.1 glycoprotein in the spinal cord and cranial nerves of the developing rat.
pubmed:affiliation
La Jolla Cancer Research Foundation, CA 92037.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.