rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
1992-11-2
|
pubmed:abstractText |
The aerobactin operon of the virulence plasmid pColV-K30 of Escherichia coli K12 consists of four genes for biosynthesis and one for transport of the siderophore. Regulation by iron occurs at the transcriptional level and is mediated by a ferrous iron binding protein designated Fur (ferric uptake regulation). The metallated Fur repressor binds at a palindromic dyad, the "iron box" operator, situated in the vicinity of the RNA polymerase attachment site of the promoter. Evidence suggests that the ferrous iron enters the C-terminal domain of Fur to cause a conformational change in the N-terminal part of the protein. This results in greatly enhanced affinity of the repressor for the operator.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0008-4166
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
38
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
728-33
|
pubmed:dateRevised |
2010-10-19
|
pubmed:meshHeading |
pubmed-meshheading:1393837-Bacterial Proteins,
pubmed-meshheading:1393837-Base Sequence,
pubmed-meshheading:1393837-Enterobactin,
pubmed-meshheading:1393837-Escherichia coli,
pubmed-meshheading:1393837-Gene Expression Regulation, Bacterial,
pubmed-meshheading:1393837-Hydroxamic Acids,
pubmed-meshheading:1393837-Iron,
pubmed-meshheading:1393837-Molecular Sequence Data,
pubmed-meshheading:1393837-Operon,
pubmed-meshheading:1393837-Plasmids,
pubmed-meshheading:1393837-Repressor Proteins,
pubmed-meshheading:1393837-Siderophores,
pubmed-meshheading:1393837-Virulence
|
pubmed:year |
1992
|
pubmed:articleTitle |
Mechanism and regulation of synthesis of aerobactin in Escherichia coli K12 (pColV-K30).
|
pubmed:affiliation |
Department of Molecular and Cellular Biology, University of California, Berkeley 94720.
|
pubmed:publicationType |
Journal Article,
Review
|