Linked Life Data

1392623

Source:http://linkedlifedata.com/resource/pubmed/id/1392623

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-10-26
pubmed:abstractText
To measure intestinal absorption of macromolecules we have developed a new technique employing synthetic polysucrose polymers as probe molecules. Polysucrose (PS) is water-soluble, nontoxic, resistant to intestinal enzymes, spherical and can be produced with a molecular weight distribution that relates to the size of many normal food proteins. Normally, a very small fraction of large molecules passes the exclusion barrier of the healthy intestine. Thus, quantification of resorbed macromolecules requires assays of high sensitivity. For detection of PS in various biological fluids, micro-ELISAs have been established. PS with a mean molecular weight of 14,700 daltons (PS 15,000) is rapidly excreted into the urine. Twenty-one healthy volunteers who orally ingested 1 g of this preparation showed a 12-hour urine excretion of 0.018% (interquartile range 0.014-0.022).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1018-2438
pubmed:author
pubmed:issnType
Print
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
220-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Chemical and physiological properties of polysucrose, a new marker of intestinal permeability to macromolecules.
pubmed:affiliation
Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't