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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-11-19
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pubmed:abstractText |
Humoral immune factors related to type 1 diabetes have been investigated in children with coeliac disease. Anti-insulin (IAAb), immunoglobulin (alpha IgAb), islet cell (ICA) and glucagon autoantibodies were examined in 15 children with coeliac disease at diagnosis (group 1), in 15 children with coeliac disease following a gluten-free diet (group 2) and in 30 control patients (groups 3 and 4). IAAb were present in 27% of group 1 and in 20% of group 2 patients and alpha IgAb were significantly increased in group 1 and 2 patients; two patients in group 2 were positive for ICA; none of the coeliac disease patients were positive for anti-glucagon antibodies. The levels of anti-gliadin antibodies in group 1 were positively correlated with those of alpha IgAb. Coeliac disease-related HLA antigens were not correlated with antibody presence. The presence of diabetes-related humoral immune factors in coeliac disease raises the question as to whether or not they are predictive of subclinical pancreatic damage or whether they are simply indicators of a more general autoimmune diathesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0803-5253
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1392382-Adolescent,
pubmed-meshheading:1392382-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1392382-Autoantibodies,
pubmed-meshheading:1392382-Celiac Disease,
pubmed-meshheading:1392382-Child,
pubmed-meshheading:1392382-Child, Preschool,
pubmed-meshheading:1392382-Diabetes Mellitus, Type 1,
pubmed-meshheading:1392382-Female,
pubmed-meshheading:1392382-Gliadin,
pubmed-meshheading:1392382-Glucagon,
pubmed-meshheading:1392382-HLA-DR Antigens,
pubmed-meshheading:1392382-Humans,
pubmed-meshheading:1392382-Immunoglobulin A,
pubmed-meshheading:1392382-Immunoglobulin G,
pubmed-meshheading:1392382-Infant,
pubmed-meshheading:1392382-Insulin,
pubmed-meshheading:1392382-Islets of Langerhans,
pubmed-meshheading:1392382-Male,
pubmed-meshheading:1392382-Phenotype
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pubmed:year |
1992
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pubmed:articleTitle |
Diabetes-related autoantibodies do appear in children with coeliac disease.
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pubmed:affiliation |
Department of Endocrinology, University La Sapienza, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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