rdf:type |
|
lifeskim:mentions |
umls-concept:C0003006,
umls-concept:C0003009,
umls-concept:C0030685,
umls-concept:C0035094,
umls-concept:C0086418,
umls-concept:C0334331,
umls-concept:C0391871,
umls-concept:C0521115,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1963578
|
pubmed:issue |
8
|
pubmed:dateCreated |
1992-11-3
|
pubmed:abstractText |
Increasing evidence indicates that angiotensin II can be formed by juxtaglomerular cells (JGC) and cosecreted with renin. We investigated the existence of this local renin-angiotensin system in a human JGC tumor, using an in vitro superfusion. The JGC tumor was found concomitantly to release renin and angiotensin I and II. Sequential addition of atrial natriuretic peptide, dopamine, and a somatostatin analog in the superfusion did not affect renin or angiotensin I and II release. The data provide evidence that the human JGC tumor in vitro generates angiotensin II, and supports its possible role as a local in vivo regulator of kidney function.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0895-7061
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
566-9
|
pubmed:dateRevised |
2009-2-24
|
pubmed:meshHeading |
pubmed-meshheading:1388967-Adult,
pubmed-meshheading:1388967-Angiotensin I,
pubmed-meshheading:1388967-Angiotensin II,
pubmed-meshheading:1388967-Atrial Natriuretic Factor,
pubmed-meshheading:1388967-Dopamine,
pubmed-meshheading:1388967-Female,
pubmed-meshheading:1388967-Humans,
pubmed-meshheading:1388967-Juxtaglomerular Apparatus,
pubmed-meshheading:1388967-Kidney Neoplasms,
pubmed-meshheading:1388967-Microscopy, Electron,
pubmed-meshheading:1388967-Octreotide,
pubmed-meshheading:1388967-Perfusion,
pubmed-meshheading:1388967-Renin
|
pubmed:year |
1992
|
pubmed:articleTitle |
Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor.
|
pubmed:affiliation |
Institute of Semeiotica Medica, University of Padova, Italy.
|
pubmed:publicationType |
Journal Article,
Case Reports
|