| pubmed-article:1387595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0014346 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0039097 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0806987 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0018850 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C1548795 | lld:lifeskim |
| pubmed-article:1387595 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:1387595 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1387595 | pubmed:dateCreated | 1992-10-7 | lld:pubmed |
| pubmed-article:1387595 | pubmed:abstractText | T lymphocyte responses to heterologous or self 65-kD heat shock protein (hsp) have been implicated in the pathogenesis of various forms of arthritis. To delineate the relationship of 65-kD hsp to different synovial fluid (SF) T cell subsets, we stimulated synovial fluid (SFMC) and peripheral blood mononuclear cells (PBMC) from patients with different inflammatory rheumatic diseases and from healthy controls with human or mycobacterial 65-kD hsp, tetanus toxoid (TT), heat-killed or live Yersinia enterocolitica. Phenotyping of the resulting T cell lines revealed an increase of up to 97% TCR-gamma delta+ lymphocytes in the 65-kD hsp-stimulated SF-derived lines. This expansion of TCR-gamma delta+ cells was less pronounced with cultures of PBMC. A preferential expansion of TCR-gamma delta+ cells was also shown after SFMC stimulation with live, but not with heat-killed Yersinia or with TT. We conclude that a common mechanism is involved in the selective expansion of TCR-gamma delta+ lymphocytes upon SFMC infection with live Yersinia or upon contact with 65-kD hsp. Out of a panel of TCR-gamma delta+ T lymphocyte clones (TLC) derived from a human 65-kD hsp-stimulated line, only a minority of TLC proliferated weakly upon restimulation with this antigen in the presence of autologous monocytes, whereas TCR-alpha beta+ TLC responded vigorously to the human 65-kD hsp and in some cases also cross-recognized the mycobacterial hsp homologue and/or heat-killed Yersinia. This implies that additional factors or cells may be present in the milieu of SFMC cultures that propagate the expansion of TCR-gamma delta+ cells in response to 65-kD hsp or live bacteria. | lld:pubmed |
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| pubmed-article:1387595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1387595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1387595 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1387595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1387595 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1387595 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:ProbstPP | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:Meyer zum... | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:FleischerBB | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:van der ZeeRR | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:MayerW PWP | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:HermansBB | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:PorallaTT | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:Van EdenWW | lld:pubmed |
| pubmed-article:1387595 | pubmed:author | pubmed-author:LohseA WAW | lld:pubmed |
| pubmed-article:1387595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1387595 | pubmed:volume | 89 | lld:pubmed |
| pubmed-article:1387595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1387595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1387595 | pubmed:pagination | 427-33 | lld:pubmed |
| pubmed-article:1387595 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1387595 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1387595 | pubmed:articleTitle | Stimulation of synovial fluid mononuclear cells with the human 65-kD heat shock protein or with live enterobacteria leads to preferential expansion of TCR-gamma delta+ lymphocytes. | lld:pubmed |
| pubmed-article:1387595 | pubmed:affiliation | First Department of Medicine, Johannes Gutenberg University, Mainz, Germany. | lld:pubmed |
| pubmed-article:1387595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1387595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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