Linked Life Data

1387318

Source:http://linkedlifedata.com/resource/pubmed/id/1387318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-9-29
pubmed:abstractText
Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who received a constant infusion schedule of 15 mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was given during the hours of 3pm to 9pm than all of the animals survived the 14 day infusion. If the maximum dose of infusion was changed so that 60% of the infusion was given at night from 3am to 9am the infusion became more toxic and all the animals died in a mean of 5.5 days. Pathologic sectioning of all the livers reflected the above outcomes with the greatest amount of hepatic necrosis in the animals on the night cycles. This study underscores the recent advances in chronobiology demonstrating that for continuous hepatic arterial infusions the timing of delivery is crucial in determining the toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0894-8569
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-93; discussion 193-4
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
The effects on toxicity of circadian patterning of continuous hepatic artery infusion.
pubmed:affiliation
Department of Surgery, St. Vincent's Hospital and Medical Center, New York, NY 10011.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't