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pubmed:abstractText |
Treatment with thyroxine or liothyronine increased the urinary excretion of free histamine in male and female rats under the influence of aminoguanidine, a histaminase inhibitor. There was no evidence for an altered catabolism of histamine in rats treated with liothyronine, since the same percentage of subcutaneously injected [(14)C]-histamine appeared unchanged in the urine. After subcutaneous injection of [(14)C]-L-histidine, rats treated with liothyronine excreted more [(14)C]-histamine than control rats. An increased formation of [(14)C]-histamine from [(14)C]-histidine could also be demonstrated in vitro, in the glandular portion of the stomach, while no increase was found in the skin.
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