Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-8-20
pubmed:abstractText
[3H]-BAY U 3405 was used to characterize the pH-dependency of the binding of various ligands to the TXA2/PGH2-receptor of human platelet membranes. Maximum binding of [3H]-BAY U 3405 is achieved at pH 5.8. In inhibition studies the ligands Daltroban, CTA2, and U 46619 also show a higher affinity at pH 5.8 compared to pH 7.4. In contrast, the ligands I-PTA-OH and GR 32191 have a higher affinity at pH 7.4. No difference is seen with SQ 29548. The ligands I-PTA-OH, GR 32191, and SQ 29548 have a second protonable group in common, which is thought to be the reason for the different pH-dependent binding.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/15-Hydroxy-11 alpha,9..., http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles, http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Phenylacetates, http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin Endoperoxides..., http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin H2, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins H, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Prostaglandin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thromboxane, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides, http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2, http://linkedlifedata.com/resource/pubmed/chemical/Thromboxanes, http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents, http://linkedlifedata.com/resource/pubmed/chemical/daltroban, http://linkedlifedata.com/resource/pubmed/chemical/ramatroban
pubmed:status
MEDLINE
pubmed:issn
0379-0363
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
222-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1385924-15-Hydroxy-11 alpha,9..., pubmed-meshheading:1385924-Blood Platelets, pubmed-meshheading:1385924-Carbazoles, pubmed-meshheading:1385924-Cell Membrane, pubmed-meshheading:1385924-Humans, pubmed-meshheading:1385924-Hydrogen-Ion Concentration, pubmed-meshheading:1385924-Kinetics, pubmed-meshheading:1385924-Ligands, pubmed-meshheading:1385924-Phenylacetates, pubmed-meshheading:1385924-Platelet Aggregation Inhibitors, pubmed-meshheading:1385924-Prostaglandin Endoperoxides, Synthetic, pubmed-meshheading:1385924-Prostaglandin H2, pubmed-meshheading:1385924-Prostaglandins H, pubmed-meshheading:1385924-Receptors, Prostaglandin, pubmed-meshheading:1385924-Receptors, Thromboxane, pubmed-meshheading:1385924-Sulfonamides, pubmed-meshheading:1385924-Thromboxane A2, pubmed-meshheading:1385924-Thromboxanes, pubmed-meshheading:1385924-Vasoconstrictor Agents
pubmed:year
1992
pubmed:articleTitle
pH-dependent binding of the TXA2/PGH2-receptor of human platelet membranes to various ligands.
pubmed:affiliation
Institut für Herz/Kreislauf- und Artheroskleroseforschung, Bayer AG, Wuppertal, Germany.
pubmed:publicationType
Journal Article, In Vitro