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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1992-11-27
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pubmed:abstractText |
The role of endogenous nitric oxide (NO) in the gastric mucosal vasodilatation induced by acute intragastric perfusion with capsaicin or close-arterial infusion of rat alpha-calcitonin gene-related peptide (CGRP) was evaluated in the pentobarbitone-anaesthetised rat using laser Doppler flowmetry (LDF). The mucosal vasodilatation induced by intraluminal capsaicin (160 microM) was dose dependently reduced by the inhibitor of NO synthesis, NG-nitro-L-arginine methyl ester (L-NAME; 1-5 mg kg-1 i.v.), effects reversed by concurrent administration of L-arginine (100 mg kg-1 i.v.). L-NAME (2 mg kg-1) induced a small reduction in the mucosal vasodilatation induced by close-arterial infusion of rat alpha-CGRP (50 pmol kg-1 min-1). These findings indicate a role of NO in the gastric vasodilatation induced by stimulation of sensory neurones with intragastric capsaicin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
218
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1385168-Amino Acid Oxidoreductases,
pubmed-meshheading:1385168-Animals,
pubmed-meshheading:1385168-Arginine,
pubmed-meshheading:1385168-Calcitonin Gene-Related Peptide,
pubmed-meshheading:1385168-Capsaicin,
pubmed-meshheading:1385168-Dose-Response Relationship, Drug,
pubmed-meshheading:1385168-Gastric Mucosa,
pubmed-meshheading:1385168-Lasers,
pubmed-meshheading:1385168-Male,
pubmed-meshheading:1385168-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:1385168-Nitric Oxide,
pubmed-meshheading:1385168-Nitric Oxide Synthase,
pubmed-meshheading:1385168-Rats,
pubmed-meshheading:1385168-Vasodilation
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pubmed:year |
1992
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pubmed:articleTitle |
Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin.
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pubmed:affiliation |
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent, UK.
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pubmed:publicationType |
Journal Article
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