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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-12-8
|
| pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M79310,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M81118,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49465,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49467,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49469,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49471,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49473,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S49475,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X63687,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X63688,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X63689,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X63690,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X65112,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/X65113
|
| pubmed:abstractText |
The t(6;9) associated with a subtype of acute myeloid leukemia (AML) was shown to generate a fusion between the 3' part of the CAN gene on chromosome 9 and the 5' part of the DEK gene on chromosome 6. The same part of the CAN gene appeared to be involved in a case of acute undifferentiated leukemia (AUL) as well, where it was fused to the SET gene. Genomic sequences around the translocation breakpoint were determined in two t(6;9) samples and in the case of the SET-CAN fusion. Although coexpression of myeloid markers and terminal deoxynucleotidyl transferase was shown to be one of the characteristics of t(6;9) AML, no addition of random nucleotides at the translocation breakpoint could be found. In addition, the breakpoint regions did not reveal heptamer-nonamer sequences, purine-pyrimidine tracts, a chi-octamer motif, or Alu repeats. The sequence in which the translocation breakpoints occurred was enriched in A/T. Notably, the specific introns in which clustering of breakpoints occurs in DEK and CAN both contain a LINE-I element. As LINE-I elements occur with a moderate frequency in the human genome, the presence of such an element in both breakpoint regions may be more than coincidental and may play a role in the translocation process.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1045-2257
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:geneSymbol |
CAN,
SET
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
227-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1384675-Acute Disease,
pubmed-meshheading:1384675-Base Sequence,
pubmed-meshheading:1384675-Chromosomes, Human, Pair 6,
pubmed-meshheading:1384675-Chromosomes, Human, Pair 9,
pubmed-meshheading:1384675-Humans,
pubmed-meshheading:1384675-Introns,
pubmed-meshheading:1384675-Leukemia,
pubmed-meshheading:1384675-Leukemia, Myeloid,
pubmed-meshheading:1384675-Molecular Sequence Data,
pubmed-meshheading:1384675-Oligonucleotide Probes,
pubmed-meshheading:1384675-Polymerase Chain Reaction,
pubmed-meshheading:1384675-Translocation, Genetic
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia.
|
| pubmed:affiliation |
Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|