| pubmed-article:1384244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1384244 | lifeskim:mentions | umls-concept:C0153690 | lld:lifeskim |
| pubmed-article:1384244 | lifeskim:mentions | umls-concept:C1337013 | lld:lifeskim |
| pubmed-article:1384244 | lifeskim:mentions | umls-concept:C1522326 | lld:lifeskim |
| pubmed-article:1384244 | lifeskim:mentions | umls-concept:C1292734 | lld:lifeskim |
| pubmed-article:1384244 | lifeskim:mentions | umls-concept:C1441129 | lld:lifeskim |
| pubmed-article:1384244 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1384244 | pubmed:dateCreated | 1992-11-4 | lld:pubmed |
| pubmed-article:1384244 | pubmed:abstractText | From 1964 to 1989, bone metastases were found in 28 of 600 patients operated on for differentiated thyroid carcinoma. Bone metastasis was the presenting symptom in 15 (54%) patients, was detected from the initial symptom in 4 (14.5%) patients, and occurred subsequently in 9 (32%) patients, with an average lag time of 4.5 years after surgical treatment. Pathological pattern of the thyroid cancer was follicular in 26 (93%) patients and papillary in 2 (7%) patients. Bone metastatic involvement was multiple in 21 (75%) patients and associated with other synchronous or metachronous distant metastases in 13 (46%) patients, especially in the lung (10 patients) or the brain (3 patients). The primary treatment of thyroid carcinoma was total thyroidectomy in all 28 patients, with additional modified neck dissection in 8 patients. All 15 patients presenting with symptoms had bone metastases demonstrated by x-ray studies. Six of the bone metastases only took up radioactive iodine 6 weeks after total thyroidectomy, as did 2 of 4 bone metastases detected at initial observation and 4 of 9 metachronous bone metastases. All 12 patients with functioning bone metastases were given radioactive iodine therapy; 4 of the metastases were surgically resected. Only 2 patients with bone metastases showed a complete response after an ablative dose of I-131; none of the metastases had been demonstrated by x-ray studies. Radioactive iodine therapy cures no more than 17% of patients with bone metastases taking up radioactive iodine and 7% of all patients with bone metastases. All patients cured of bone metastases were given radioactive iodine, either alone, or combined with other treatment.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1384244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1384244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1384244 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1384244 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1384244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1384244 | pubmed:issn | 0364-2313 | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:FossatiPP | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:CarpentierPP | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:DecoulxMM | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:LefebvreJJ | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:WemeauJ LJL | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:ProyeC ACA | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:GoropoulosAA | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:CarnailleB... | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:DromerD HDH | lld:pubmed |
| pubmed-article:1384244 | pubmed:author | pubmed-author:GontierA JAJ | lld:pubmed |
| pubmed-article:1384244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1384244 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:1384244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1384244 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1384244 | pubmed:pagination | 640-5; discussion 645-6 | lld:pubmed |
| pubmed-article:1384244 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:meshHeading | pubmed-meshheading:1384244-... | lld:pubmed |
| pubmed-article:1384244 | pubmed:articleTitle | Is it still worthwhile to treat bone metastases from differentiated thyroid carcinoma with radioactive iodine? | lld:pubmed |
| pubmed-article:1384244 | pubmed:affiliation | Department of General and Endocrine Surgery, CHUP Lille, France. | lld:pubmed |
| pubmed-article:1384244 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1384244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1384244 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1384244 | lld:pubmed |
