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rdf:type |
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lifeskim:mentions |
umls-concept:C0024518,
umls-concept:C0087048,
umls-concept:C0205147,
umls-concept:C0439828,
umls-concept:C0870441,
umls-concept:C0871261,
umls-concept:C1521761,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707391,
umls-concept:C2911692
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pubmed:issue |
19
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pubmed:dateCreated |
1992-11-10
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pubmed:databankReference |
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pubmed:abstractText |
Dominant expression of T-cell receptor (TCR) alpha or beta chain variable region (V alpha or V beta) gene families has been observed in the T-cell response to some conventional peptide antigens. Current models for the interaction of TCR V region elements with different determinants of a major histocompatibility complex (MHC)-peptide complex, the normal TCR ligand, suggest that the TCR V-J junctional region (CDR3, where J is joining) is the primary contact with a peptide epitope and that other TCR V region segments may interact directly with neighboring MHC determinants. This suggests that V alpha or V beta dominance in a specific response can be MHC-selected. In this case, if related peptides bind to an MHC molecule in a similar orientation, they could select for identical V alpha or V beta dominance even if they are noncrossreactive at the level of T-cell activation. We have screened for this possibility by introducing minimal conservative substitutions in a synthetic peptide, YYEELLKYYEELLK, that is presented to T cells in association with an uncommon A beta E alpha d mixed Ia isotype. We report here that the peptide variant FFEELLKFFEELLK is noncrossreactive with YYEELLKYYEELLK but appears to preserve the same MHC binding motif since T-cell responses are restricted to the same mixed A beta E alpha isotype. Although the two peptides are noncrossreactive in either direction, the same members of the V alpha 4 gene family are dominantly expressed in T cells specific for either peptide. We conclude that the similar topography of the two MHC-peptide complexes gives functional significance to a unique A beta E alpha determinant that selects for V alpha 4 dominance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-1309938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-1315417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-1598575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-1730914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2153168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2406610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2421164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2455603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2456856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2461560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2463672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2784852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2971535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-2995827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3086873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3208747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3456487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3487085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3493320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3493439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-3839904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-6158548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-6809821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1384036-7301588
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Poly A,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8874-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1384036-Amino Acid Sequence,
pubmed-meshheading:1384036-Animals,
pubmed-meshheading:1384036-Antibodies,
pubmed-meshheading:1384036-Antigen-Presenting Cells,
pubmed-meshheading:1384036-Base Sequence,
pubmed-meshheading:1384036-Cloning, Molecular,
pubmed-meshheading:1384036-Cross Reactions,
pubmed-meshheading:1384036-DNA,
pubmed-meshheading:1384036-Gene Library,
pubmed-meshheading:1384036-Haplotypes,
pubmed-meshheading:1384036-L Cells (Cell Line),
pubmed-meshheading:1384036-Lymphocyte Activation,
pubmed-meshheading:1384036-Macromolecular Substances,
pubmed-meshheading:1384036-Major Histocompatibility Complex,
pubmed-meshheading:1384036-Mice,
pubmed-meshheading:1384036-Mice, Inbred BALB C,
pubmed-meshheading:1384036-Mice, Inbred C3H,
pubmed-meshheading:1384036-Molecular Sequence Data,
pubmed-meshheading:1384036-Oligodeoxyribonucleotides,
pubmed-meshheading:1384036-Peptides,
pubmed-meshheading:1384036-Poly A,
pubmed-meshheading:1384036-Polymerase Chain Reaction,
pubmed-meshheading:1384036-RNA,
pubmed-meshheading:1384036-RNA, Messenger,
pubmed-meshheading:1384036-Receptors, Antigen, T-Cell,
pubmed-meshheading:1384036-T-Lymphocytes,
pubmed-meshheading:1384036-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Major histocompatibility complex determinants select T-cell receptor alpha chain variable region dominance in a peptide-specific response.
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pubmed:affiliation |
Cancer Center, University of Rochester School of Medicine, NY 14642.
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pubmed:publicationType |
Journal Article
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