Linked Life Data

1383583

Source:http://linkedlifedata.com/resource/pubmed/id/1383583

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-11-3
pubmed:abstractText
This study was designed to assess whether development of the astrocytes in central nervous system (CNS) is delayed in victims of the sudden infant death syndrome (SIDS), and to try the classification of astrocytes by a morphological method. The glial fibrillary acidic protein (GFAP) is the major component of astrocytic fiber and is characteristic of astrocytes in the human CNS. An immunohistochemical study identificating this protein was carried out on infant brains to evaluate astrocytes. Morphologically 39 brains of infants aging under 12 months old, that including 10 asphyxia, 13 respiratory infections and 16 SIDS cases, were stained for GFAP by the peroxidase-anti-peroxidase (PAP) method. According to their staining pattern astrocytes were classified into 4 cell types: Type I cells were seen during the non-proliferating period, Type II cells during the low-proliferating period, Type III cells during the moderate-proliferating period and Type IV cells during the high-proliferating period. On the basis of this classification of astrocytes, it was observed that the first and most reactive pattern of physiological proliferation was in infant brains four months old after birth in the asphyxia cases. The staining grade of astrocytes was significantly less in white matter in the SIDS victims compared with age-matched of the respiratory infections and asphyxia. Therefore, we suggest that development of brain in the SIDS cases is delayed to controls and that the SIDS is associated with a developmental CNS disorder. Among 3 group cases the retarded staining pattern of the astrocytes in SIDS is interesting and might give a helpful approach to diagnosis of the cause of death for SIDS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0047-1887
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-97
pubmed:dateRevised
2006-9-4
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Immunohistochemical classification of astrocytes in infants by glial fibrillary acidic protein staining and application to forensic practice.
pubmed:affiliation
Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
pubmed:publicationType
Journal Article