Linked Life Data

1383338

Source:http://linkedlifedata.com/resource/pubmed/id/1383338

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1992-11-25
pubmed:abstractText
AIDS dementia complex is a common neurologic disorder in later stages of HIV-1 infection. Because virus-specific CTL have been shown to contribute to neurologic disease in certain viral illnesses, we examined the cerebrospinal fluid of HIV-1-infected persons with various stages of AIDS dementia complex for the presence of HIV-1-specific CTL. In five of six subjects studied, HIV-1-specific CTL were identified in the cerebrospinal fluid. These CTL were directed at epitopes within the gag, reverse transcriptase, envelope, and nef proteins and restricted by HLA class I Ag. In four of these subjects, virus-specific CTL were detected in higher numbers in the cerebrospinal fluid compared to the peripheral blood, suggesting a specific recruitment to or local induction within the nervous system. These studies demonstrate the presence of a vigorous and broadly directed CTL response to HIV-1 in the central nervous system of infected persons with AIDS dementia complex, and provide immunologic evidence of localized intrathecal infection. Although HIV-1-specific CTL may serve to inhibit viral replication in the central nervous system, the presence of a persistent CTL response in the central nervous system may also contribute to the neurologic disorders characteristic of HIV-1 infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3113-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:1383338-AIDS Dementia Complex, pubmed-meshheading:1383338-Amino Acid Sequence, pubmed-meshheading:1383338-Cerebrospinal Fluid, pubmed-meshheading:1383338-Cytotoxicity, Immunologic, pubmed-meshheading:1383338-Epitopes, pubmed-meshheading:1383338-Gene Products, env, pubmed-meshheading:1383338-Gene Products, gag, pubmed-meshheading:1383338-Gene Products, nef, pubmed-meshheading:1383338-HIV-1, pubmed-meshheading:1383338-HLA Antigens, pubmed-meshheading:1383338-Humans, pubmed-meshheading:1383338-Immunity, Cellular, pubmed-meshheading:1383338-Immunophenotyping, pubmed-meshheading:1383338-Molecular Sequence Data, pubmed-meshheading:1383338-RNA-Directed DNA Polymerase, pubmed-meshheading:1383338-T-Lymphocytes, Cytotoxic, pubmed-meshheading:1383338-beta-Galactosidase, pubmed-meshheading:1383338-nef Gene Products, Human Immunodeficiency Virus
pubmed:year
1992
pubmed:articleTitle
Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
pubmed:affiliation
Infectious Disease Unit, Massachusetts General Hospital, Boston 02114.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't