| pubmed-article:1383259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1383259 | lifeskim:mentions | umls-concept:C0030362 | lld:lifeskim |
| pubmed-article:1383259 | lifeskim:mentions | umls-concept:C0079772 | lld:lifeskim |
| pubmed-article:1383259 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:1383259 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:1383259 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1383259 | pubmed:dateCreated | 1992-10-29 | lld:pubmed |
| pubmed-article:1383259 | pubmed:abstractText | Papio hamadryas baboons in the Sukhumi colony develop enzootic outbreaks of malignant lymphomas with an incidence of about 1.5% per year among adults of the high-risk stock. We investigated the surface phenotypes of cells from normal and lymphomatous animals using antibodies against human lymphocyte antigens. We found that more than 80% of the lymphomas that developed during the last 3 years were characterized histologically to be of the peripheral T cell type. Generally, the lymphomatous cells also expressed high levels of MHC class II DR protein, CD18 (LFA-1 beta chain), and CD45RO. Surprisingly, these cells also expressed on their surface two proteins previously characterized as being relatively B cell-restricted: CD40 and Bgp95. These proteins were never found on the peripheral blood T cells from normal animals. The expression of these two gene products was confirmed by RNA blotting and immunoprecipitation. In most cases, the two B cell-associated proteins were expressed on the predominant T cell subsets; we found both B cell proteins on CD4+, CD8+ as well as on the CD4/8 double-positive cells when these subsets were expressed at high levels. About 90% of these animals are seropositive for Herpesvirus papio and human T cell leukemia virus-1 (HTLV-1) before developing outright lymphomas. In all of the lymphoma samples, HTLV-1 tax DNA sequences were detected by PCR amplification. Whether or not HTLV-1 or the Herpesvirus papio gene products influence the surface expression of CD40 and Bgp95 remains to be determined. | lld:pubmed |
| pubmed-article:1383259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1383259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1383259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1383259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1383259 | pubmed:month | May | lld:pubmed |
| pubmed-article:1383259 | pubmed:issn | 0271-9142 | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:LapinB ABA | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:YakovlevaL... | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:ClarkE AEA | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:IndzhiiaL VLV | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:TorresRR | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:LicciardiK... | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:OverbaughJJ | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:ChikobavaM... | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:KlotzI NIN | lld:pubmed |
| pubmed-article:1383259 | pubmed:author | pubmed-author:IndzhiiaV OVO | lld:pubmed |
| pubmed-article:1383259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1383259 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:1383259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1383259 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1383259 | pubmed:pagination | 225-36 | lld:pubmed |
| pubmed-article:1383259 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1383259 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1383259 | pubmed:articleTitle | Baboon T cell lymphomas expressing the B cell-associated surface proteins CD40 and Bgp95. | lld:pubmed |
| pubmed-article:1383259 | pubmed:affiliation | Institute of Experimental Pathology and Therapy, USSR Academy of Medical Sciences, Sukhumi. | lld:pubmed |
| pubmed-article:1383259 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1383259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1383259 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
