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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-10-29
|
| pubmed:abstractText |
Papio hamadryas baboons in the Sukhumi colony develop enzootic outbreaks of malignant lymphomas with an incidence of about 1.5% per year among adults of the high-risk stock. We investigated the surface phenotypes of cells from normal and lymphomatous animals using antibodies against human lymphocyte antigens. We found that more than 80% of the lymphomas that developed during the last 3 years were characterized histologically to be of the peripheral T cell type. Generally, the lymphomatous cells also expressed high levels of MHC class II DR protein, CD18 (LFA-1 beta chain), and CD45RO. Surprisingly, these cells also expressed on their surface two proteins previously characterized as being relatively B cell-restricted: CD40 and Bgp95. These proteins were never found on the peripheral blood T cells from normal animals. The expression of these two gene products was confirmed by RNA blotting and immunoprecipitation. In most cases, the two B cell-associated proteins were expressed on the predominant T cell subsets; we found both B cell proteins on CD4+, CD8+ as well as on the CD4/8 double-positive cells when these subsets were expressed at high levels. About 90% of these animals are seropositive for Herpesvirus papio and human T cell leukemia virus-1 (HTLV-1) before developing outright lymphomas. In all of the lymphoma samples, HTLV-1 tax DNA sequences were detected by PCR amplification. Whether or not HTLV-1 or the Herpesvirus papio gene products influence the surface expression of CD40 and Bgp95 remains to be determined.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0271-9142
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
225-36
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1383259-Animals,
pubmed-meshheading:1383259-Antigens, CD,
pubmed-meshheading:1383259-Antigens, CD40,
pubmed-meshheading:1383259-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1383259-Antigens, Surface,
pubmed-meshheading:1383259-B-Lymphocytes,
pubmed-meshheading:1383259-Base Sequence,
pubmed-meshheading:1383259-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1383259-Flow Cytometry,
pubmed-meshheading:1383259-Genes, pX,
pubmed-meshheading:1383259-HTLV-I Infections,
pubmed-meshheading:1383259-Herpesvirus 1, Cercopithecine,
pubmed-meshheading:1383259-Human T-lymphotropic virus 1,
pubmed-meshheading:1383259-Immunophenotyping,
pubmed-meshheading:1383259-Lymphoma, T-Cell,
pubmed-meshheading:1383259-Molecular Sequence Data,
pubmed-meshheading:1383259-Monkey Diseases,
pubmed-meshheading:1383259-Papio,
pubmed-meshheading:1383259-Polymerase Chain Reaction,
pubmed-meshheading:1383259-T-Lymphocytes,
pubmed-meshheading:1383259-T-Lymphocytes, Regulatory
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Baboon T cell lymphomas expressing the B cell-associated surface proteins CD40 and Bgp95.
|
| pubmed:affiliation |
Institute of Experimental Pathology and Therapy, USSR Academy of Medical Sciences, Sukhumi.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|