Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-10-20
pubmed:abstractText
We have studied the expression and function of c-kit on subsets of mouse thymocytes. c-kit was primarily expressed on subpopulations of CD4-CD8-CD3- triple negative (TN) cells. The strongest c-kit expression was associated with subsets that represent the least mature TN cells, including CD44+CD25- TN, and a subpopulation of CD25+ TN. These cells were also Thy-1lo, H-2Khi TSA-1hi, HSAlo, B220-, Mac-1-, and Gr-1-. Additionally, the recently described pre-TN thymocyte population (CD4loCD3-CD8-) was also c-kit+. CD25+ TN thymocytes proliferated in the presence of IL-7 and stem cell factor (the ligand for c-kit), and this proliferation was completely inhibited in the presence of anti-c-kit. Furthermore, the addition of anti-c-kit to 2-deoxyguanosine-treated fetal thymic lobes undergoing reconstitution with fetal liver-derived precursor cells inhibited their T cell differentiation potential. These observations indicate an important role for c-kit/stem cell factor interactions during early thymocyte development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation..., http://linkedlifedata.com/resource/pubmed/chemical/Hematopoietic Cell Growth Factors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Stem Cell Factor
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
149
pubmed:geneSymbol
c-kit
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2281-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:1382094-Animals, pubmed-meshheading:1382094-Antigens, CD3, pubmed-meshheading:1382094-Antigens, CD4, pubmed-meshheading:1382094-Antigens, CD8, pubmed-meshheading:1382094-Antigens, Differentiation, T-Lymphocyte, pubmed-meshheading:1382094-Female, pubmed-meshheading:1382094-Hematopoietic Cell Growth Factors, pubmed-meshheading:1382094-Interleukin-7, pubmed-meshheading:1382094-Lymphocyte Activation, pubmed-meshheading:1382094-Male, pubmed-meshheading:1382094-Mice, pubmed-meshheading:1382094-Mice, Inbred BALB C, pubmed-meshheading:1382094-Pregnancy, pubmed-meshheading:1382094-Protein-Tyrosine Kinases, pubmed-meshheading:1382094-Proto-Oncogene Proteins, pubmed-meshheading:1382094-Proto-Oncogene Proteins c-kit, pubmed-meshheading:1382094-Receptors, Antigen, T-Cell, pubmed-meshheading:1382094-Receptors, Interleukin-2, pubmed-meshheading:1382094-Stem Cell Factor, pubmed-meshheading:1382094-T-Lymphocytes, pubmed-meshheading:1382094-Thymus Gland
pubmed:year
1992
pubmed:articleTitle
Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.
pubmed:affiliation
DNAX Research Institute, Palo Alto, CA 94304.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't