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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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|
pubmed:dateCreated |
1992-10-9
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|
pubmed:abstractText |
The effect of substance P on nicotinic acetylcholine receptor function was examined in Torpedo electroplaque membranes. The peptide inhibited carbamylcholine-stimulated 22Na+ efflux in a concentration-dependent manner. By irreversibly blocking spare receptors with alpha-bungarotoxin, the IC50 for substance P was shown to be less than 3 microM. Inhibition by substance P was slow relative to receptor activation by carbamylcholine, consistent with an enhancement of desensitization or a slow allosteric block.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jul
|
|
pubmed:issn |
0006-8993
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
24
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|
pubmed:volume |
586
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
348-51
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1381656-Animals,
pubmed-meshheading:1381656-Bungarotoxins,
pubmed-meshheading:1381656-Carbachol,
pubmed-meshheading:1381656-Cell Membrane,
pubmed-meshheading:1381656-Electric Organ,
pubmed-meshheading:1381656-Kinetics,
pubmed-meshheading:1381656-Receptors, Nicotinic,
pubmed-meshheading:1381656-Sodium,
pubmed-meshheading:1381656-Sodium Radioisotopes,
pubmed-meshheading:1381656-Substance P,
pubmed-meshheading:1381656-Torpedo
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
Substance P inhibits carbamylcholine-stimulated 22Na+ efflux from acetylcholine receptor-enriched Torpedo electroplaque membrane vesicles.
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|
pubmed:affiliation |
Department of Pharmacology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6400.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
