|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
3
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|
pubmed:dateCreated |
1992-9-30
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pubmed:abstractText |
The sialogogic response of submandibular glands to analogs of the C-terminal hexapeptide of substance P with various amino acids at the N-terminus was investigated in urethane-anesthetized rats. The rank order of potencies was as follows: SP greater than (pGlu6)SP6-11 much greater than (Dab6)SP6-11 greater than (Orn6)SP6-11 greater than (Gln6)SP6-11 greater than (Lys6)SP6-11 much greater than (Ala6)SP6-11. These results suggest that the sialogogic activity of the analogs of the C-terminal hexapeptide is influenced by the steric effects of the N-terminal amino acid, and the nature of its side chain is of particular importance.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-5198
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
58
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
325-8
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
|
pubmed:year |
1992
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pubmed:articleTitle |
Sialogogic effects on rat submandibular gland of analogs of the C-terminal hexapeptide of substance P.
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|
pubmed:affiliation |
Department of Dental Pharmacology, School of Dentistry, Nippon Dental University, Japan.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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