Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-9-22
|
| pubmed:abstractText |
Hydrodynamic heteropore flow models for transport of solutes across alveolar epithelial tissue have been developed. A two-size cylindrical pore model and a similar parallel-plate model were formulated, tested and used to predict effective pore sizes from literature data on transport in bullfrog, canine and rat lungs. The best fit equivalent pore-size estimates were obtained using a modified, nonlinear least squares procedure, with alveolar surface area to volume ratio (S/V) and small-pore area fraction of total pore area as parameters. Small-pore and large-pore width estimates of 4 nm (84% of total flow area) and 10 nm, respectively, with an average deviation of 20% from experimentally derived permeabilities were obtained from the bullfrog alveolar epithelium parallel-plate pore model (13 solutes, diameters 0.3 to 2.8 nm). The equivalent cylindrical pore model diameter estimates were 5 nm and 10 nm, with small-pore area fraction and percentage deviations similar to the parallel-plate model estimates. Eighty-eight percent of the bulk water driven by a sucrose osmotic gradient was predicted to be transported through the small pores. The rat alveolus parallel-plate pore model (6 solutes) yielded small-pore and large-pore widths of 0.4 nm and 50 nm, respectively. Clearance rate-constant data for dextran macromolecules (3,000 to 250,000 Daltons), using a single parallel-plate pore model, resulted in a pore width estimate of 98 nm for canine alveoli with an average deviation of the predicted rate constants of 18% from literature experimental values. In all cases tested, the parallel-plate pore model predicted lower small-pore size estimates than did the cylindrical pore model, and both models had appreciably smaller percentage deviations from experimental data than previous models.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0090-6964
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
481-94
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1380785-Animals,
pubmed-meshheading:1380785-Biological Transport,
pubmed-meshheading:1380785-Capillary Permeability,
pubmed-meshheading:1380785-Dextrans,
pubmed-meshheading:1380785-Diffusion,
pubmed-meshheading:1380785-Dogs,
pubmed-meshheading:1380785-Endothelium, Vascular,
pubmed-meshheading:1380785-Epithelium,
pubmed-meshheading:1380785-Models, Biological,
pubmed-meshheading:1380785-Molecular Weight,
pubmed-meshheading:1380785-Particle Size,
pubmed-meshheading:1380785-Pulmonary Alveoli,
pubmed-meshheading:1380785-Rats,
pubmed-meshheading:1380785-Reference Values
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
A pore transport model for pulmonary alveolar epithelium.
|
| pubmed:affiliation |
Department of Chemical Engineering, University of Illinois, Chicago 60612.
|
| pubmed:publicationType |
Journal Article
|