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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-9-24
|
| pubmed:abstractText |
Recent studies have shown that hepatitis C virus antibodies are present in a large proportion of patients with autoimmune hepatitis type 2. We have studied 83 patients with liver/kidney microsome antibody-positive type 1 hepatitis. Hepatitis C virus antibodies were sought in every case by second-generation tests (hepatitis C virus enzyme-linked immunosorbent assay and recombinant immunoblot assay). Hepatitis C virus RNA sequences were sought in 22 patients (12 with recombinant immunoblot assay-positive results and 10 with recombinant immunoblot assay-negative results) by means of polymerase chain reaction and by use of primers located in the 5' noncoding region. Sixty-four patients (77%) had positive results for hepatitis C virus antibodies in the enzyme-linked immunosorbent assay test, and 41 (49.3%) were confirmed by recombinant immunoblot assay. Hepatitis C virus RNA sequences were found in all the recombinant immunoblot assay-positive patients but in none of the 10 who were recombinant immunoblot assay-negative. The recombinant immunoblot assay-negative patients were younger than those who were positive (13 +/- 11 vs. 50 +/- 11 years) and had higher gamma-globulin levels and liver/kidney microsome antibody-positive type 1 titers (61% had a titer of 1:1,000 or more, vs. only 17% of the recombinant immunoblot assay-positive patients).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Bretylium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/anti-liver kidney microsome antibody,
http://linkedlifedata.com/resource/pubmed/chemical/iodobenzyltrimethylammonium
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0270-9139
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
630-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1380479-Adolescent,
pubmed-meshheading:1380479-Adult,
pubmed-meshheading:1380479-Aged,
pubmed-meshheading:1380479-Alanine Transaminase,
pubmed-meshheading:1380479-Autoantibodies,
pubmed-meshheading:1380479-Autoimmune Diseases,
pubmed-meshheading:1380479-Bretylium Compounds,
pubmed-meshheading:1380479-Child,
pubmed-meshheading:1380479-Child, Preschool,
pubmed-meshheading:1380479-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1380479-Female,
pubmed-meshheading:1380479-Hepatitis Antibodies,
pubmed-meshheading:1380479-Hepatitis C,
pubmed-meshheading:1380479-Hepatitis C Antibodies,
pubmed-meshheading:1380479-Humans,
pubmed-meshheading:1380479-Male,
pubmed-meshheading:1380479-Middle Aged,
pubmed-meshheading:1380479-Polymerase Chain Reaction
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Liver/kidney microsome antibody type 1 and hepatitis C virus infection.
|
| pubmed:affiliation |
Service de Bactério-virologie, Hôpital Pitié-Salpêtrière, Paris, France.
|
| pubmed:publicationType |
Journal Article
|