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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-9-16
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pubmed:abstractText |
The minimum structural requirements for peptide interactions with major histocompatibility complex (MHC) class II molecules and with T cell receptors (TCRs) were examined. In this report we show that substituting alanines at all but five amino acids in the myelin basic protein (MBP) peptide Ac1-11 does not alter its ability to bind A alpha uA beta u (MHC class II molecules), to stimulate specific T cells and, surprisingly, to induce experimental autoimmune encephalomyelitis (EAE) in (PL/J x SJL/J)F1 mice. Most other amino acid side chains in the Ac1-11 peptide are essentially irrelevant for T cell stimulation and for disease induction. Further analysis revealed that binding to A alpha uA beta u occurred with a peptide that consists mainly of alanines and only three of the original residues of Ac1-11. Moreover, when used as a coimmunogen with MBP Ac1-11, this peptide inhibited EAE. The finding that a specific in vivo response can be generated by a peptide containing only five native residues provides evidence that disease-inducing TCRs recognize only a very short sequence of the MHC-bound peptide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1309938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1578131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1689345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1697306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1719536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-1739971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2189723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2295089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2409602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2413363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2414848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2439915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2455603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2478291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2480602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-2995495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-3261393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-3490919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1380066-3497349
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
176
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1380066-Amino Acid Sequence,
pubmed-meshheading:1380066-Animals,
pubmed-meshheading:1380066-Autoimmune Diseases,
pubmed-meshheading:1380066-Encephalomyelitis,
pubmed-meshheading:1380066-Histocompatibility Antigens Class II,
pubmed-meshheading:1380066-Mice,
pubmed-meshheading:1380066-Molecular Sequence Data,
pubmed-meshheading:1380066-Myelin Basic Proteins,
pubmed-meshheading:1380066-Peptides,
pubmed-meshheading:1380066-Receptors, Antigen, T-Cell
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pubmed:year |
1992
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pubmed:articleTitle |
A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis.
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pubmed:affiliation |
Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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