| pubmed-article:1379801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0033164 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:1379801 | lifeskim:mentions | umls-concept:C0966504 | lld:lifeskim |
| pubmed-article:1379801 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1379801 | pubmed:dateCreated | 1992-9-4 | lld:pubmed |
| pubmed-article:1379801 | pubmed:abstractText | The cleavage properties of a trans-acting hammerhead ribozyme targeted 51 bases upstream of the putative splicing branch point in the hamster prion pre-mRNA intron were investigated in cell-free model systems in vitro. The specificity of cleavage was demonstrated by the inability of this ribozyme to cleave a non-homologous synthetic message encoding part of the beta amyloid peptide precursor, beta APP, and by the inability of the prion pre-mRNA to be cleaved by a ribozyme targeted to beta amyloid peptide precursor mRNA. Also, the addition of total RNA isolated from rat brain had only a minimal effect on the cleavage of the prion substrate pre-mRNA by the ribozyme. Finally neither the presence of 100 ng of nuclear or cytoplasmic proteins were found to affect the rate of cleavage in vitro. | lld:pubmed |
| pubmed-article:1379801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1379801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1379801 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1379801 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1379801 | pubmed:author | pubmed-author:MillerD LDL | lld:pubmed |
| pubmed-article:1379801 | pubmed:author | pubmed-author:RubensteinRR | lld:pubmed |
| pubmed-article:1379801 | pubmed:author | pubmed-author:DenmanR BRB | lld:pubmed |
| pubmed-article:1379801 | pubmed:author | pubmed-author:PurowBB | lld:pubmed |
| pubmed-article:1379801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1379801 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:1379801 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:1379801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1379801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1379801 | pubmed:pagination | 1171-7 | lld:pubmed |
| pubmed-article:1379801 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:meshHeading | pubmed-meshheading:1379801-... | lld:pubmed |
| pubmed-article:1379801 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1379801 | pubmed:articleTitle | Hammerhead ribozyme cleavage of hamster prion pre-mRNA in complex cell-free model systems. | lld:pubmed |
| pubmed-article:1379801 | pubmed:affiliation | New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314. | lld:pubmed |
| pubmed-article:1379801 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1379801 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1379801 | lld:pubmed |
