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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5071
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pubmed:dateCreated |
1992-9-8
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pubmed:abstractText |
A Src homology 3 (SH3) region is a sequence of approximately 50 amino acids found in many nonreceptor tyrosine kinases and other proteins. Deletion of the SH3 region from the protein encoded by the c-abl proto-oncogene activates the protein's transforming capacity, thereby suggesting the participation of the SH3 region in the negative regulation of transformation. A complementary DNA was isolated that encoded a protein, 3BP-1, to which the SH3 region of Abl bound with high specificity and to which SH3 regions from other proteins bound differentially. The sequence of the 3BP-1 protein is similar to that of a COOH-terminal segment of Bcr and to guanosine triphosphatase-activating protein (GAP)-rho, which suggests that it might have GAP activity for Ras-related proteins. The 3BP-1 protein may therefore be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bcr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcr,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins pp60(c-src),
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rho Factor,
http://linkedlifedata.com/resource/pubmed/chemical/ras GTPase-Activating Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
257
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pubmed:geneSymbol |
c-abl
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
803-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1379745-3T3 Cells,
pubmed-meshheading:1379745-Amino Acid Sequence,
pubmed-meshheading:1379745-Animals,
pubmed-meshheading:1379745-Binding Sites,
pubmed-meshheading:1379745-Chimera,
pubmed-meshheading:1379745-Cloning, Molecular,
pubmed-meshheading:1379745-GTPase-Activating Proteins,
pubmed-meshheading:1379745-Gene Library,
pubmed-meshheading:1379745-Genes, abl,
pubmed-meshheading:1379745-Genes, src,
pubmed-meshheading:1379745-Glutathione Transferase,
pubmed-meshheading:1379745-Mice,
pubmed-meshheading:1379745-Molecular Sequence Data,
pubmed-meshheading:1379745-Oncogene Proteins,
pubmed-meshheading:1379745-Plasmids,
pubmed-meshheading:1379745-Polymerase Chain Reaction,
pubmed-meshheading:1379745-Prosencephalon,
pubmed-meshheading:1379745-Protein-Tyrosine Kinases,
pubmed-meshheading:1379745-Proteins,
pubmed-meshheading:1379745-Proto-Oncogene Proteins,
pubmed-meshheading:1379745-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:1379745-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:1379745-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:1379745-Recombinant Fusion Proteins,
pubmed-meshheading:1379745-Restriction Mapping,
pubmed-meshheading:1379745-Rho Factor,
pubmed-meshheading:1379745-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1379745-ras GTPase-Activating Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.
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pubmed:affiliation |
Rockefeller University, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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