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| pubmed-article:1379564 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:1379564 | pubmed:dateCreated | 1992-9-10 | lld:pubmed |
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| pubmed-article:1379564 | pubmed:abstractText | The human salivary amylase genes are associated with two inserted elements, a gamma-actin-processed pseudogene and an endogenous retroviral-like element. To test the contribution of these inserted elements to tissue specificity, 25 lines of transgenic mice carrying 10 amylase constructs were established. A 1-kb fragment of AMY1C (-1003 to +2) was found to be sufficient for parotid-specific expression of a human growth hormone reporter gene. The 1-kb fragment is entirely derived from inserted sequences. Deletion from -1003 to -826 resulted in reduced levels of transgene expression and loss of tissue specificity. The fragment -1003 to -327 was sufficient to transfer parotid specificity to the thymidine kinase promoter. The data demonstrate that the functional tissue-specific promoter of human AMY1C is derived from inserted sequences and that parotid expression can be conferred by sequences derived solely from the retrovirus. A role for retrotransposition in the evolution of gene regulation is indicated by these and other recent observations. | lld:pubmed |
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| pubmed-article:1379564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1379564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1379564 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1379564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1379564 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1379564 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:1379564 | pubmed:author | pubmed-author:MeislerM HMH | lld:pubmed |
| pubmed-article:1379564 | pubmed:author | pubmed-author:RosenbergM... | lld:pubmed |
| pubmed-article:1379564 | pubmed:author | pubmed-author:SamuelsonL... | lld:pubmed |
| pubmed-article:1379564 | pubmed:author | pubmed-author:SnowC MCM | lld:pubmed |
| pubmed-article:1379564 | pubmed:author | pubmed-author:TingC NCN | lld:pubmed |
| pubmed-article:1379564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1379564 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1379564 | pubmed:geneSymbol | AMY1C | lld:pubmed |
| pubmed-article:1379564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1379564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1379564 | pubmed:pagination | 1457-65 | lld:pubmed |
| pubmed-article:1379564 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1379564 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1379564 | pubmed:articleTitle | Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. | lld:pubmed |
| pubmed-article:1379564 | pubmed:affiliation | Department of Human Genetics, University of Michigan, Ann Arbor 48109-0618. | lld:pubmed |
| pubmed-article:1379564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1379564 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1379564 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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