Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-9-1
|
| pubmed:abstractText |
The purpose of this paper is the genetic visualization by in situ hybridization of 130 sex-linked recessive lethals plus a non-lethal induced by I-R dysgenesis. This collection of lethals involves inducer strains which differ in the position of the I elements on the X chromosomes. The I-R interaction was strong. Our previous results have shown that about 30% of the induced recessive lethals are associated with cytologically visible chromosomal rearrangements. (1) The rearrangements induced by I-R-type hybrid dysgenesis often exhibit homology with the I factor at the level of one or both junction points, depending on the types of chromosome rearrangements. These results suggest that the chromosome rearrangements arise directly from the transposition of I elements. However, the breakpoints of some types of cytologically non-visible deficiencies and of 2 small cytologically visible deficiencies do not present detectable homology with the I factor. (2) The majority of rearrangements do not involve the I elements already present on the paternal X chromosome. (3) The hybridization signal distributions on the X chromosome are not uniform. They present peaks of various heights which may correspond to specific anchoring areas of copies of I in the course of integration. (4) The data presented here agree with the literature with respect to the mean number of copies of I per X chromosome and to the excess of copies of I at locus 1A. Two rearrangement formation mechanisms are envisaged: crossing-over and 'target' exchanges.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0027-5107
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
268
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
265-85
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:1379333-Animals,
pubmed-meshheading:1379333-Chi-Square Distribution,
pubmed-meshheading:1379333-Chromosome Aberrations,
pubmed-meshheading:1379333-Chromosome Deletion,
pubmed-meshheading:1379333-Chromosome Inversion,
pubmed-meshheading:1379333-Crossing Over, Genetic,
pubmed-meshheading:1379333-DNA Transposable Elements,
pubmed-meshheading:1379333-Drosophila melanogaster,
pubmed-meshheading:1379333-Female,
pubmed-meshheading:1379333-Genes, Lethal,
pubmed-meshheading:1379333-Genes, Recessive,
pubmed-meshheading:1379333-Genetic Linkage,
pubmed-meshheading:1379333-Hybridization, Genetic,
pubmed-meshheading:1379333-Mutation,
pubmed-meshheading:1379333-Nucleic Acid Hybridization,
pubmed-meshheading:1379333-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:1379333-Translocation, Genetic,
pubmed-meshheading:1379333-X Chromosome
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
I-R hybrid dysgenesis in Drosophila melanogaster. Use of in situ hybridization to show the association of I factor DNA with induced sex-linked recessive lethals.
|
| pubmed:affiliation |
Laboratoire de Biologie Générale, Université Paris-Sud, Orsay, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|