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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-9-1
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pubmed:abstractText |
Exogenous interferon-alpha (IFN-alpha) and interferon-beta (IFN-beta) (type I IFNs) are known to suppress the IFN-gamma-dependent expression of class II MHC (Ia) antigens on macrophages (M phi). We report here that the endogenous type I IFNs produced by M phi in response to IFN inducers regulate Ia expression of the M phi themselves. Coculture of M phi with IFN-gamma and polyinosinic-polycytidylic acid [poly(I):poly(C)] resulted in the reduction of Ia expression in comparison with those cultured without poly(I):poly(C). Pretreatment of M phi with poly(I):poly(C) or a bacterial lipopolysaccharide (LPS), which is also a potent IFN inducer, in vitro or in vivo, before being exposed to IFN-gamma was also effective in suppressing the Ia expression. Such suppression was abolished by the addition of anti-IFN-alpha/beta antibodies to the M phi culture along with IFN-gamma. M phi cultured with L-cell conditioned medium (LCM) containing M-CSF were less capable of expressing Ia antigens than those cultured without LCM. The Ia-expressing ability of LCM-treated M phi was also restored by the addition of anti-IFN-alpha/beta antibodies. M phi in the early stage of sterile inflammation were less responsive to IFN-gamma than those in the late stage. These results suggest that endogenous type I IFNs, which are produced in response to natural or synthetic IFN-inducers, regulate M phi Ia expression in an autocrinal manner.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Inducers,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Poly I-C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor Factors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0197-8357
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
Spec No
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1379284-Animals,
pubmed-meshheading:1379284-Blotting, Northern,
pubmed-meshheading:1379284-Down-Regulation,
pubmed-meshheading:1379284-Female,
pubmed-meshheading:1379284-Histocompatibility Antigens Class II,
pubmed-meshheading:1379284-Inflammation,
pubmed-meshheading:1379284-Interferon Inducers,
pubmed-meshheading:1379284-Interferon Type I,
pubmed-meshheading:1379284-Interferon-gamma,
pubmed-meshheading:1379284-Iodine Radioisotopes,
pubmed-meshheading:1379284-Lipopolysaccharides,
pubmed-meshheading:1379284-Macrophages,
pubmed-meshheading:1379284-Male,
pubmed-meshheading:1379284-Mice,
pubmed-meshheading:1379284-Mice, Inbred C3H,
pubmed-meshheading:1379284-Poly I-C,
pubmed-meshheading:1379284-RNA,
pubmed-meshheading:1379284-Recombinant Proteins,
pubmed-meshheading:1379284-Suppressor Factors, Immunologic
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pubmed:year |
1992
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pubmed:articleTitle |
Suppression of macrophage Ia antigen expression by endogenous interferon-alpha/beta.
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pubmed:affiliation |
Department of Zoology, Faculty of Science, Kyoto University.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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