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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5067
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pubmed:dateCreated |
1992-8-18
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pubmed:abstractText |
Immature T cells and some T cell hybridomas undergo apoptotic cell death when activated through the T cell receptor complex, a phenomenon that is probably related to antigen induced negative selection of developing T cells. This activation-induced apoptosis depends on active protein and RNA synthesis in the dying cells, although none of the genes required for this process have previously been identified. Antisense oligonucleotides corresponding to c-myc block the constitutive expression of c-Myc protein in T cell hybridomas and interfere with all aspects of activation-induced apoptosis without affecting lymphokine production in these cells. These data indicate that c-myc expression is a necessary component of activation-induced apoptosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
257
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pubmed:geneSymbol |
c-fos,
c-myc
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
212-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1378649-Animals,
pubmed-meshheading:1378649-Antigens, CD3,
pubmed-meshheading:1378649-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1378649-Base Sequence,
pubmed-meshheading:1378649-Blotting, Western,
pubmed-meshheading:1378649-Cell Death,
pubmed-meshheading:1378649-Flow Cytometry,
pubmed-meshheading:1378649-Gene Expression,
pubmed-meshheading:1378649-Genes, fos,
pubmed-meshheading:1378649-Genes, myc,
pubmed-meshheading:1378649-Hybridomas,
pubmed-meshheading:1378649-Lymphocyte Activation,
pubmed-meshheading:1378649-Molecular Sequence Data,
pubmed-meshheading:1378649-Oligonucleotides, Antisense,
pubmed-meshheading:1378649-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:1378649-RNA,
pubmed-meshheading:1378649-Receptors, Antigen, T-Cell,
pubmed-meshheading:1378649-T-Lymphocytes,
pubmed-meshheading:1378649-Transcription, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.
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pubmed:affiliation |
Department of Immunology, University of Alberta, Edmonton, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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