rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5067
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pubmed:dateCreated |
1992-8-18
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pubmed:abstractText |
As a first step in a program to use genetically altered mice in the study of memory mechanisms, mutant mice were produced that do not express the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII). The alpha-CaMKII is highly enriched in postsynaptic densities of hippocampus and neocortex and may be involved in the regulation of long-term potentiation (LTP). Such mutant mice exhibited mostly normal behaviors and presented no obvious neuroanatomical defects. Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact. Despite normal postsynaptic mechanisms, these mice are deficient in their ability to produce LTP and are therefore a suitable model for studying the relation between LTP and learning processes.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
257
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1378648-Animals,
pubmed-meshheading:1378648-Behavior, Animal,
pubmed-meshheading:1378648-Blotting, Northern,
pubmed-meshheading:1378648-Blotting, Southern,
pubmed-meshheading:1378648-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:1378648-Chromosome Mapping,
pubmed-meshheading:1378648-DNA,
pubmed-meshheading:1378648-Electrophysiology,
pubmed-meshheading:1378648-Female,
pubmed-meshheading:1378648-Hippocampus,
pubmed-meshheading:1378648-Learning,
pubmed-meshheading:1378648-Male,
pubmed-meshheading:1378648-Mice,
pubmed-meshheading:1378648-Mice, Inbred BALB C,
pubmed-meshheading:1378648-Mice, Mutant Strains,
pubmed-meshheading:1378648-Mutagenesis, Site-Directed,
pubmed-meshheading:1378648-Plasmids,
pubmed-meshheading:1378648-Protein Kinases,
pubmed-meshheading:1378648-RNA,
pubmed-meshheading:1378648-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1378648-Synapses,
pubmed-meshheading:1378648-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.
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pubmed:affiliation |
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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