Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5067
pubmed:dateCreated
1992-8-18
pubmed:abstractText
As a first step in a program to use genetically altered mice in the study of memory mechanisms, mutant mice were produced that do not express the alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII). The alpha-CaMKII is highly enriched in postsynaptic densities of hippocampus and neocortex and may be involved in the regulation of long-term potentiation (LTP). Such mutant mice exhibited mostly normal behaviors and presented no obvious neuroanatomical defects. Whole cell recordings reveal that postsynaptic mechanisms, including N-methyl-D-aspartate (NMDA) receptor function, are intact. Despite normal postsynaptic mechanisms, these mice are deficient in their ability to produce LTP and are therefore a suitable model for studying the relation between LTP and learning processes.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:1378648-Animals, pubmed-meshheading:1378648-Behavior, Animal, pubmed-meshheading:1378648-Blotting, Northern, pubmed-meshheading:1378648-Blotting, Southern, pubmed-meshheading:1378648-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:1378648-Chromosome Mapping, pubmed-meshheading:1378648-DNA, pubmed-meshheading:1378648-Electrophysiology, pubmed-meshheading:1378648-Female, pubmed-meshheading:1378648-Hippocampus, pubmed-meshheading:1378648-Learning, pubmed-meshheading:1378648-Male, pubmed-meshheading:1378648-Mice, pubmed-meshheading:1378648-Mice, Inbred BALB C, pubmed-meshheading:1378648-Mice, Mutant Strains, pubmed-meshheading:1378648-Mutagenesis, Site-Directed, pubmed-meshheading:1378648-Plasmids, pubmed-meshheading:1378648-Protein Kinases, pubmed-meshheading:1378648-RNA, pubmed-meshheading:1378648-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:1378648-Synapses, pubmed-meshheading:1378648-Transfection
pubmed:year
1992
pubmed:articleTitle
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.
pubmed:affiliation
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, MA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't