Linked Life Data

1377055

Source:http://linkedlifedata.com/resource/pubmed/id/1377055

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-7-29
pubmed:abstractText
We studied the effects of six cycles of repeated cyclophosphamide (CTX) therapy followed by restorative therapy with either granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF on the hematopoietic stem cell compartment. Stem cell function was assessed by serially transferring bone marrow cells from CTX-CSF-treated mice into lethally irradiated recipient mice. Bone marrow cells from mice that initially received either G-CSF or GM-CSF after CTX therapy more rapidly lost the ability to repopulate the recipient lymphoid organs, showed a dramatic loss of hematopoietic progenitors, a more rapid loss of CFU-S capacity, and a 40% to 50% reduction in marrow repopulating ability (MRA). Interleukin-1 (IL-1) appeared to have little effect on the CTX-treated mice when used alone. However, when administered before the CTX-CSF regimen, IL-1 prevented the stem cell depletion as determined by CFU-C, CFU-S, and MRA through the serial transplantation procedures. These results support the hypothesis that repeated treatments with myelosuppressive drugs followed by stimulation with the CSFs may induce damage to the host stem cell compartment, and further suggest that pretreatment with IL-1 before CTX therapy may prevent this stem cell damage.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-83
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1377055-Animals, pubmed-meshheading:1377055-Antigens, Ly, pubmed-meshheading:1377055-Bone Marrow, pubmed-meshheading:1377055-Bone Marrow Cells, pubmed-meshheading:1377055-Bone Marrow Transplantation, pubmed-meshheading:1377055-Cyclophosphamide, pubmed-meshheading:1377055-Dose-Response Relationship, Drug, pubmed-meshheading:1377055-Female, pubmed-meshheading:1377055-Granulocyte Colony-Stimulating Factor, pubmed-meshheading:1377055-Granulocyte-Macrophage Colony-Stimulating Factor, pubmed-meshheading:1377055-Hematopoiesis, pubmed-meshheading:1377055-Hematopoietic Stem Cells, pubmed-meshheading:1377055-Interleukin-1, pubmed-meshheading:1377055-Mice, pubmed-meshheading:1377055-Mice, Inbred C57BL, pubmed-meshheading:1377055-Radiation Chimera, pubmed-meshheading:1377055-Time Factors
pubmed:year
1992
pubmed:articleTitle
Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy.
pubmed:affiliation
Biological Carcinogenesis & Development Program, Program Resources, Inc/DynCorp, National Cancer Institute-Frederick Cancer Research & Development Center 21702-1201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.