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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-7-27
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pubmed:abstractText |
Nitric oxide (NO) is an important messenger both systemically and in the CNS. In digital Ca2+ imaging and patch-clamp experiments, clinically available nitroso compounds that generate NO are shown to inhibit responses mediated by the NMDA subtype of the glutamate receptor on rat cortical neurons in vitro. A mechanism of action for this effect was investigated by using the specific NO-generating agent S-nitrosocysteine. We propose that free sulfhydryl groups on the NMDA receptor-channel complex react to form one or more S-nitrosothiols in the presence of NO. If vicinal thiol groups react in this manner, they can form a disulfide bond(s), which is thought to constitute the redox modulatory site of the receptor, resulting in a relatively persistent blockade of NMDA responses. These reactions with NO can afford protection from NMDA receptor-mediated neurotoxicity. Our results demonstrate a new pathway for NO regulation of physiological function that is not via cGMP, but instead involves reactions with membrane-bound thiol groups on the NMDA receptor-channel complex.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1087-99
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1376999-Alkylating Agents,
pubmed-meshheading:1376999-Animals,
pubmed-meshheading:1376999-Calcium,
pubmed-meshheading:1376999-Electrophysiology,
pubmed-meshheading:1376999-Intracellular Membranes,
pubmed-meshheading:1376999-Ion Channels,
pubmed-meshheading:1376999-Kainic Acid,
pubmed-meshheading:1376999-N-Methylaspartate,
pubmed-meshheading:1376999-Neurons,
pubmed-meshheading:1376999-Nitric Oxide,
pubmed-meshheading:1376999-Nitroso Compounds,
pubmed-meshheading:1376999-Oxidation-Reduction,
pubmed-meshheading:1376999-Potassium,
pubmed-meshheading:1376999-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1992
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pubmed:articleTitle |
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex.
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pubmed:affiliation |
Department of Neurology, Children's Hospital, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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