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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0002198,
umls-concept:C0010454,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036630,
umls-concept:C0076175,
umls-concept:C0205112,
umls-concept:C0221908,
umls-concept:C0678587,
umls-concept:C0683927,
umls-concept:C1306673,
umls-concept:C1413514,
umls-concept:C1511572,
umls-concept:C1704788,
umls-concept:C2827446
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pubmed:issue |
3
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pubmed:dateCreated |
1992-7-10
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pubmed:abstractText |
Production of several proteins by rat Sertoli cells is dependent on the stage of the cycle of the seminiferous epithelium. The authors have determined steady state levels and follicle-stimulating hormone responsiveness of three Sertoli cell products in culture media of rat seminiferous tubule segments at different stages of the epithelial cycle: SGP-2 (sulfated glycoprotein-2), alpha 2-macroglobulin, and testibumin. Basal SGP-2 levels were twofold higher in stages VII through VIII compared with stages XIII to I to VI (P less than 0.05). Highest basal alpha 2-macroglobulin levels were found in stages II through VIII; this was about 35% greater than in stages XIII through I of the cycle (P less than 0.05). Basal testibumin levels were twofold higher in stages II through VI compared with stages IX through XII of the cycle. Follicle-stimulating hormone had no effect on SGP-2, but by contrast it (50 mg/L) increased the level of alpha 2-macroglobulin significantly (P less than 0.05) in stages XIII through I. Follicle-stimulating hormone treatment (10 mg/L) elevated testibumin levels at each stage-pool by about 40% (P less than 0.05). The current results using staged tubular segments in vitro demonstrate cyclic basal steady-state levels of the three proteins along the seminiferous tubules and follicle-stimulating hormone regulation of alpha 2-macroglobulin and testibumin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Clusterin,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Molecular Chaperones,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Psap protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Saposins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Macroglobulins
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pubmed:status |
MEDLINE
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pubmed:issn |
0196-3635
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
208-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1376307-Animals,
pubmed-meshheading:1376307-Clusterin,
pubmed-meshheading:1376307-Follicle Stimulating Hormone,
pubmed-meshheading:1376307-Glycoproteins,
pubmed-meshheading:1376307-Male,
pubmed-meshheading:1376307-Molecular Chaperones,
pubmed-meshheading:1376307-Proteins,
pubmed-meshheading:1376307-Rats,
pubmed-meshheading:1376307-Rats, Inbred Strains,
pubmed-meshheading:1376307-Saposins,
pubmed-meshheading:1376307-Seminiferous Tubules,
pubmed-meshheading:1376307-Spermatogenesis,
pubmed-meshheading:1376307-alpha-Macroglobulins
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pubmed:articleTitle |
Basal and FSH-stimulated steady state levels of SGP-2, alpha 2-macroglobulin, and testibumin in culture media of rat seminiferous tubules at defined stages of the epithelial cycle.
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pubmed:affiliation |
Department of Anatomy, University of Turku, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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