Linked Life Data

1376222

Source:http://linkedlifedata.com/resource/pubmed/id/1376222

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
279
pubmed:dateCreated
1992-7-16
pubmed:abstractText
The purpose of this study was to investigate the relationship between the appearance of basal lamina components (Type IV collagen and laminin) and the development of cartilage canals. In the distal femoral epiphyses from developing rats, the distribution of basal lamina components in the cartilage canal was examined immunohistochemically. The formation of cartilage canals from the perichondrium was first observed on the fifth day after birth. By Day 8, a few cartilage canals penetrated the epiphyseal cartilage and considerably increased in size and length. By light microscopic immunohistochemistry, reticular structures stained with anti-Type IV collagen and antilaminin antibodies were observed in the cartilage canals. In the early development of cartilage canals, however, immunostaining by anti-Type IV collagen antibodies was weaker than that by antilaminin antibodies. In eight-day-old rats, the laminin-positive reticular structures were more densely colored and more widely distributed in the canal than the Type IV collagen-positive ones. Type IV collagen was found around the endothelial cells of the developing capillaries by electron microscopic immunohistochemistry. Laminin was observed in the cytoplasm of the mesenchymal fibroblastic cells and their pericellular matrix as well as in the capillary basal lamina. These immunohistochemical electron microscopic observations can explain the differences that are observed in Type IV collagen and laminin immunostaining patterns as cartilage canals develop. Laminin synthesized by the mesenchymal fibroblastic cells may promote the migration and the outgrowth of endothelial cells in the formation of cartilage canals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
292-8
pubmed:dateRevised
2005-3-3
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Immunohistochemical localization of basal lamina components in the developing rat epiphyseal cartilage canals.
pubmed:affiliation
Department of Orthopaedic Surgery, Kumamoto University Medical School, Japan.
pubmed:publicationType
Journal Article