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rdf:type |
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lifeskim:mentions |
umls-concept:C0010029,
umls-concept:C0015780,
umls-concept:C0024554,
umls-concept:C0026809,
umls-concept:C0034693,
umls-concept:C0042444,
umls-concept:C0051348,
umls-concept:C0185125,
umls-concept:C0348005,
umls-concept:C0600688,
umls-concept:C0808279,
umls-concept:C1521991,
umls-concept:C2003941,
umls-concept:C2348438,
umls-concept:C2698297
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pubmed:issue |
3
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pubmed:dateCreated |
1992-7-7
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pubmed:abstractText |
The application of alpha-cyclodextrin (alpha-CD) as an alternative vehicle for water insoluble and volatile chemicals was investigated in toxicity studies of p-chloro-alpha, alpha, alpha-trifluorotoluene (CTFT). Groups of F344 rats and B6C3F1 mice of each sex were administered CTFT (97% pure) by gavage in either corn oil or alpha-CD aqueous formulations daily for 14 consecutive days. The dose levels used were 10 (mice only), 50, 400, and 1000 mg/kg for corn oil vehicle and 10, 50, and 400 mg/kg (maximum achievable dose at gavage volume of 5 ml/kg) for alpha-CD vehicle. With both vehicles CTFT and alpha 2u-globulin were found to accumulate in the male rat kidney after 14 days of exposure and a dose-related toxic nephropathy was observed at dose of 50 mg/kg or higher. The hepatocellular hypertrophy and cytoplasmic vacuolation of the adrenal cortex which appeared in dosed male and female rats were also found to be independent of vehicle. Clinical pathology findings suggested a mild anemia and cholestasis in rats. With both vehicles no tissue bioaccumulation of CTFT was found in male or female mice. Vehicle-independent hepatocellular hypertrophy and cholestasis were also observed in mice at doses of 400 and 1000 mg/kg. In conclusion, the alpha-CD vehicle does not affect the toxic responses of CTFT in both sexes of both species. The results of the studies suggest that alpha-CD may be an appropriate alternative vehicle for toxicity studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-chloro-alpha,alpha,alpha-trifluoro...,
http://linkedlifedata.com/resource/pubmed/chemical/Alpha-Globulins,
http://linkedlifedata.com/resource/pubmed/chemical/Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Corn Oil,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclodextrins,
http://linkedlifedata.com/resource/pubmed/chemical/Pharmaceutical Vehicles,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Toluene,
http://linkedlifedata.com/resource/pubmed/chemical/alpha 2u globulin,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Cyclodextrins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-cyclodextrin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0272-0590
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
460-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1375921-Alpha-Globulins,
pubmed-meshheading:1375921-Animals,
pubmed-meshheading:1375921-Blood Cell Count,
pubmed-meshheading:1375921-Body Weight,
pubmed-meshheading:1375921-Capsules,
pubmed-meshheading:1375921-Corn Oil,
pubmed-meshheading:1375921-Cyclodextrins,
pubmed-meshheading:1375921-Female,
pubmed-meshheading:1375921-Humans,
pubmed-meshheading:1375921-Infant, Newborn,
pubmed-meshheading:1375921-Kidney,
pubmed-meshheading:1375921-Liver,
pubmed-meshheading:1375921-Male,
pubmed-meshheading:1375921-Mice,
pubmed-meshheading:1375921-Mice, Inbred Strains,
pubmed-meshheading:1375921-Organ Size,
pubmed-meshheading:1375921-Pharmaceutical Vehicles,
pubmed-meshheading:1375921-Proteins,
pubmed-meshheading:1375921-Rats,
pubmed-meshheading:1375921-Rats, Inbred F344,
pubmed-meshheading:1375921-Species Specificity,
pubmed-meshheading:1375921-Toluene,
pubmed-meshheading:1375921-alpha-Cyclodextrins
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pubmed:year |
1992
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pubmed:articleTitle |
Application of molecular encapsulation for toxicology studies: comparative toxicity of p-Chloro-alpha, alpha, alpha-trifluorotoluene in alpha-cyclodextrin vehicle versus corn oil vehicle in male and female Fischer 344 rats and B6C3F1 mice.
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pubmed:affiliation |
National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
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pubmed:publicationType |
Journal Article
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