Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1992-7-9
pubmed:abstractText
The murine myeloproliferative syndrome induced by the myeloproliferative sarcoma virus (MPSV) has numerous similarities to human primary myelofibrosis. We have shown that medium conditioned by spleen cells of MPSV-infected mice has the capacity to support the growth of primitive blast cell colonies. The detection of this activity associated with MPSV infection stimulated us to characterize the hematopoietins responsible for this activity. Northern blot analysis showed a large increase, or induction, of interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage-CSF (CSF-1), and granulocyte-CSF (G-CSF) transcripts in the hematopoietic organs of MPSV-infected mice; however, no IL-3 transcript could be detected in either MPSV-infected or normal mice. Significant levels of IL-1 alpha, IL-6, G-CSF, and CSF-1 bioactivities were found in the serum of MPSV-infected mice, but not in controls. Additionally, analysis of medium conditioned by spleen cells of MPSV-infected mice showed the presence of tumor necrosis factor alpha bioactivity. The increased production of cytokines that are able to stimulate pluripotent hematopoietic stem cells corroborates the hypothesis of a possible involvement of hematopoietic growth factors in the development of some myeloproliferative disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3179-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1375844-Animals, pubmed-meshheading:1375844-Blotting, Northern, pubmed-meshheading:1375844-Cells, Cultured, pubmed-meshheading:1375844-Gene Expression, pubmed-meshheading:1375844-Granulocyte Colony-Stimulating Factor, pubmed-meshheading:1375844-Hematopoietic Cell Growth Factors, pubmed-meshheading:1375844-Interleukin-6, pubmed-meshheading:1375844-Liver, pubmed-meshheading:1375844-Macrophage Colony-Stimulating Factor, pubmed-meshheading:1375844-Male, pubmed-meshheading:1375844-Mice, pubmed-meshheading:1375844-Mice, Inbred DBA, pubmed-meshheading:1375844-Myeloproliferative Disorders, pubmed-meshheading:1375844-RNA, Messenger, pubmed-meshheading:1375844-Retroviridae Infections, pubmed-meshheading:1375844-Spleen, pubmed-meshheading:1375844-Thymus Gland, pubmed-meshheading:1375844-Transcription, Genetic, pubmed-meshheading:1375844-Tumor Necrosis Factor-alpha
pubmed:year
1992
pubmed:articleTitle
Enhanced hematopoietic growth factor production in an experimental myeloproliferative syndrome.
pubmed:affiliation
Unité d'Oncogènése Appliquée, INSERM U268, Hôpital Paul Brousse, Villejuif, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't